Articles liés à Diclofenac Na Matrix Tablet: Formulation Development...

Diclofenac Na Matrix Tablet: Formulation Development and Release Kinetics Study - Couverture souple

Ahmed, Tajnin

 
9783847336891: Diclofenac Na Matrix Tablet: Formulation Development and Release Kinetics Study
Couverture souple
ISBN 10 : 3847336894 ISBN 13 : 9783847336891
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

In this research work sustained release Diclofenac Sodium matrix tablets were prepared by using different polymers like Kollidon SR, Poly Ethylene Glycol and HPMC at different percentages. 5 batches of 260mg tablets were prepared by direct compression and wet granulation methods and by using different shapes in an attempt towards modification of dissolution behavior of the drug. The used shapes of tablets were caplet oval, round oval add flat oval. Dissolution study of each of the formulation was monitored at pH 1.2, 6.5 and 7.4. An increase drug release took place in case of higher pH i.e. at pH 7.4 & pH 6.5 but in lower pH i.e. at pH 1.2 a little amount of drug release was obtained. Due to the acidic nature if drug its release was lower at acidic pH. Again in case of shape at higher pH 6.5 & 7.4 the release was better from the caplet oval shape than that of round oval and flat oval. A cooperative higher release of drug was obtained from the polymer HPMC at 10% from the Diclofenac Sodium matrix tablet, which contain fixed amount of Kollidon SR, which was 30% them that of the PEG of 10%. The drug release was also found to be better in case of direct compression method.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l'auteur

Tajnin Ahmed obtained her M.Pharm degree in Pharmaceutical Science from University of Science and Technology, Bangladesh. Currently she is working as an Asst. Prof. in the Dept. of Pharmacy, Stamford University Bangladesh (SUB). Mohammad Abusyed is working in ICDDR,B as Business Development Manager. Dewan T. Akhtar is Lecturer in SUB.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3847336894
ISBN 13 
9783847336891
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne