Interplay between DNA replication and repair: The proposed model for replication restart - Couverture souple

Pourahmad Jaktaji, Razieh

 
9783847339014: Interplay between DNA replication and repair: The proposed model for replication restart
Couverture souple
ISBN 10 : 384733901X ISBN 13 : 9783847339014
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

DNA replication complexes assembled at origins of replication are intrinsically highly processive. However, their progression is often hindered by lesions in or on the DNA. There is growing evidence that RNA polymerase stalled itself at a lesion in the template strand is a major obstacle, especially in UV-irradiated cells. The data presented in this book provide information and propose model on how modulation of RNA polymerase activity might enable UV-irradiated cells lacking RuvABC to overcome obstacles caused by the stalling of RNA polymerases at UV-induced DNA lesions. The proposed model for replication restart relies on PriA protein, but does not require RecBCD and thus does not proceed via recombination and Holliday junction resolution or even via processing of a DNA end by RecBCD. However, it does require the UvrABC excision repair pathway and RecG protein. The book describes studies indicating that in rpo* cells, replication forks may run directly into lesions in DNA rather than into RNA polymerase stalled at lesions, and that this leads to direct fork rescue without recombination with the aid of SOS induction, which increases excision repair to remove lesions at other sites.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

DNA replication complexes assembled at origins of replication are intrinsically highly processive. However, their progression is often hindered by lesions in or on the DNA. There is growing evidence that RNA polymerase stalled itself at a lesion in the template strand is a major obstacle, especially in UV-irradiated cells. The data presented in this book provide information and propose model on how modulation of RNA polymerase activity might enable UV-irradiated cells lacking RuvABC to overcome obstacles caused by the stalling of RNA polymerases at UV-induced DNA lesions. The proposed model for replication restart relies on PriA protein, but does not require RecBCD and thus does not proceed via recombination and Holliday junction resolution or even via processing of a DNA end by RecBCD. However, it does require the UvrABC excision repair pathway and RecG protein. The book describes studies indicating that in rpo* cells, replication forks may run directly into lesions in DNA rather than into RNA polymerase stalled at lesions, and that this leads to direct fork rescue without recombination with the aid of SOS induction, which increases excision repair to remove lesions at other sites.

Biographie de l'auteur

Dr. Razieh Pourahmad Jaktaji has obtained her Ph D degree in Genetics in 2002. Since then she has worked in Shahrekord University. She is the author and co-author of several papers published in reputed journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
384733901X
ISBN 13 
9783847339014
Reliure
Broché
Nombre de pages
200
Coordonnées du fabricant
non disponible
Personne responsable
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