Physico-Chemical Properties of Drug-Additive Systems: Micellization of Amphiphilic Drugs: Composition, Interaction and Stability of the Aggregates - Couverture souple

Abdul Rub, Malik; -ud-Din, Kabir

 
9783847372851: Physico-Chemical Properties of Drug-Additive Systems: Micellization of Amphiphilic Drugs: Composition, Interaction and Stability of the Aggregates
Couverture souple
ISBN 10 : 3847372858 ISBN 13 : 9783847372851
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

A most common challenge faced by pharmaceutical scientists as well as industry is to design and develop drugs with good aqueous solubility while simultaneously retaining potency and selectivity. This problem can be overpowered by the use of mixed micelles of drug–surfactant or surfactant–surfactant. The results would be helpful towards the development of drug formulations which will expectedly help in removing their disadvantages towards accumulation within bio-membranes. The amphiphilic drugs, because of their surfactant-like nature, exhibit concentration, temperature and pH-dependent phase separation (clouding), therefore, it is important to have knowledge of clouding behavior of the drugs in designing more effective drug-carrier combinations. With this idea in mind, effects of various additives, viz., electrolytes, non-electrolytes, alcohols, surfactants, sugars, and amino acids have been examined on clouding behavior of some amphiphilic drugs.

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Présentation de l'éditeur

A most common challenge faced by pharmaceutical scientists as well as industry is to design and develop drugs with good aqueous solubility while simultaneously retaining potency and selectivity. This problem can be overpowered by the use of mixed micelles of drug–surfactant or surfactant–surfactant. The results would be helpful towards the development of drug formulations which will expectedly help in removing their disadvantages towards accumulation within bio-membranes. The amphiphilic drugs, because of their surfactant-like nature, exhibit concentration, temperature and pH-dependent phase separation (clouding), therefore, it is important to have knowledge of clouding behavior of the drugs in designing more effective drug-carrier combinations. With this idea in mind, effects of various additives, viz., electrolytes, non-electrolytes, alcohols, surfactants, sugars, and amino acids have been examined on clouding behavior of some amphiphilic drugs.

Biographie de l'auteur

Dr. Malik Abdul Rub completed his B.Sc.and M.Sc. from Aligarh Muslim University with the specialization in Industrial Chemistry and also completed his Ph.D. in 2011 from same university. He is currently working as an Assistant Professor in Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah-21589, Saudi Arabia.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3847372858
ISBN 13 
9783847372851
Reliure
Broché
Nombre de pages
168
Coordonnées du fabricant
non disponible
Personne responsable
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