Articles liés à Detection of Methylated RAR in the Urine of Bladder...

Detection of Methylated RAR in the Urine of Bladder Cancer Patients: Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine - Couverture souple

Ibrahim, Ahmed; Eissa, Sanaa

 
9783847379249: Detection of Methylated RAR in the Urine of Bladder Cancer Patients: Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine
Couverture souple
ISBN 10 : 3847379240 ISBN 13 : 9783847379249
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RARβ2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RARβ2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RARβ2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RARβ2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RARβ2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%.

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Présentation de l'éditeur

Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RARβ2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RARβ2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RARβ2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RARβ2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RARβ2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%.

Biographie de l'auteur

Ass-lecturer of biochemistry- faculty of pharmacy, Misr University for Science and Technology . Coauthor: Sanaa Eissa:Prof of medical biochemistry and molecular biology at Ain Shams University Faculty of medicineLeading research in developing novel diagnostic tests for bladder cancer with 51 international publications

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3847379240
ISBN 13 
9783847379249
Reliure
Broché
Nombre de pages
248
Coordonnées du fabricant
non disponible
Personne responsable
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