Study of Few Polysubstituted Piperidone Analogs - Couverture souple

De, Sourav; Banerjee, Subhasis

 
9783848404971: Study of Few Polysubstituted Piperidone Analogs
Couverture souple
ISBN 10 : 3848404974 ISBN 13 : 9783848404971
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Dipeptidyl Peptidase-IV (DPP-IV) was found to be one of the emerging targets in the field of antidiabetic drug development. In recent years, Piperidone analogs have shown their application in the field of diabetology as observed in the crystallographic structure of DPP-IV. All the ligand molecules were designed considering the pharmacophoric features of the GGO901 (Co-crystallised ligand of DPP-IV with the PDB entry-2OQI). It was thought worthwhile to perform docking study by extracting the crystallographic structure of Dipeptidyl Peptidase-IV inhibitor with all the virtually developed molecules to ensure the better binding energy which would be well able to explain the ligand target interaction of novel piperidone analogs, actively inhibiting DPP-IV enzyme. Based on the docking output, a few novel imidazole linked piperidone analogs were synthesized & as a part of the structure elucidation process various spectroscopic data were collected and subsequently analysed. All the analytically proven synthesized compounds were further sent for biological evaluation.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848404974
ISBN 13 
9783848404971
Reliure
Broché
Nombre de pages
72
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne