Synthesis, structure & bioactivity of organotin(IV)hydrazone compounds: Synthesis and biological studies of organotin(IV) complexes of pyruvic acid phenylhydrazone with thiocyanate co-ligand - Couverture souple

Affan, M. A.; Salam, M. A.

 
9783848405695: Synthesis, structure & bioactivity of organotin(IV)hydrazone compounds: Synthesis and biological studies of organotin(IV) complexes of pyruvic acid phenylhydrazone with thiocyanate co-ligand
Couverture souple
ISBN 10 : 3848405695 ISBN 13 : 9783848405695
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s) yielded the organotin(IV) complexes (2-11). Molecular structural assessments of the complexes (2-11) have been based on data from UV-Vis, IR, 1H and 13C NMR spectral studies. The molecular structure of HPAPD (1) has also been determined by X-ray diffraction. Spectroscopic data suggested that HPAPD (1) is coordinated to the tin(IV) atom via carboxylate-O and azomethine-N atoms and acted as a mononegative bidentate chelating agent in all the organotin(IV) complexes (2-11). Spectral data indicated that thiocyanate group is N-coordinated to the Sn(IV) ion in the complexes (7-9). The coordination number of tin in all the organotin(IV) complexes (2-11) is five. The cytotoxicity of the compounds 1-11 was studied against Artemia salina. The free ligand (1) and its organotin(IV) complexes (2-11) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenese, Escherichia coli and Salmonella typhi. The biological studies showed that all organotin(IV) complexes (2-11) are more potent antibacterial and cytotoxic agents than their free ligand (1).

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s) yielded the organotin(IV) complexes (2-11). Molecular structural assessments of the complexes (2-11) have been based on data from UV-Vis, IR, 1H and 13C NMR spectral studies. The molecular structure of HPAPD (1) has also been determined by X-ray diffraction. Spectroscopic data suggested that HPAPD (1) is coordinated to the tin(IV) atom via carboxylate-O and azomethine-N atoms and acted as a mononegative bidentate chelating agent in all the organotin(IV) complexes (2-11). Spectral data indicated that thiocyanate group is N-coordinated to the Sn(IV) ion in the complexes (7-9). The coordination number of tin in all the organotin(IV) complexes (2-11) is five. The cytotoxicity of the compounds 1-11 was studied against Artemia salina. The free ligand (1) and its organotin(IV) complexes (2-11) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenese, Escherichia coli and Salmonella typhi. The biological studies showed that all organotin(IV) complexes (2-11) are more potent antibacterial and cytotoxic agents than their free ligand (1).

Biographie de l'auteur

Dr. M. A. Affan is an Associate Professor in the Department of Chemistry, Universiti Malaysia Sarawak. He is a guest editor of OJIC. M. A. Salam is a PhD research student in the Department of Chemistry, Universiti Malaysia Sarawak. Their research interests are in the field of Organometallic Chemistry.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848405695
ISBN 13 
9783848405695
Reliure
Broché
Nombre de pages
76
Coordonnées du fabricant
non disponible
Personne responsable
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