Pyrazoline Derivatives as Antitubercular Agents: Synthesis, Characterization & Evaluation of Some Novel Pyrazoline Derivatives - Couverture souple

Jain, Vaibhav; Jain, Priyal; Jain, Surendra

 
9783848406340: Pyrazoline Derivatives as Antitubercular Agents: Synthesis, Characterization & Evaluation of Some Novel Pyrazoline Derivatives
Couverture souple
ISBN 10 : 3848406349 ISBN 13 : 9783848406340
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the death of 2–3 million people annually and for a global economic toll of $12 billion each year. Thus, there is an urgent need to develop new therapeutics for tuberculosis, to reduce the duration of treatment and to provide a more effective therapy for MDR TB and for latent tuberculosis infection. In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR spectroscopy data and elemental analysis. . The antitubercular activity of these compounds were evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M. Tuberculosis compared with standard INH, RIF & ETM.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the death of 2–3 million people annually and for a global economic toll of $12 billion each year. Thus, there is an urgent need to develop new therapeutics for tuberculosis, to reduce the duration of treatment and to provide a more effective therapy for MDR TB and for latent tuberculosis infection. In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR spectroscopy data and elemental analysis. . The antitubercular activity of these compounds were evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M. Tuberculosis compared with standard INH, RIF & ETM.

Biographie de l'auteur

Mr. Vaibhav Jain, Asst. Prof. SIRT-Pharmacy, Bhopal; has degree of M.Pharmacy with specialization in Pharmaceutical Chemistry. He is the author of numerous scientific publications along with various presentations in National & International Conferences. He was associated with Central Drug Research Institute,Lucknow during his research work.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848406349
ISBN 13 
9783848406340
Reliure
Broché
Nombre de pages
92
Coordonnées du fabricant
non disponible
Personne responsable
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