Articles liés à Monocyte NADPH Oxidase: Role of Pattern Recognition...

Monocyte NADPH Oxidase: Role of Pattern Recognition Receptors: An Overview: - Couverture souple

Elsori, Deena

 
9783848418138: Monocyte NADPH Oxidase: Role of Pattern Recognition Receptors: An Overview:
Couverture souple
ISBN 10 : 3848418134 ISBN 13 : 9783848418138
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Activation of the NADPH oxidase enzyme complex results in the production of the oxygen free radical, superoxide anion (O2.-). Superoxide anion is critical for host defense against fungal and bacterial pathogens and efficient immune responses; however, uncontrolled monocyte-derived O2.- may contribute to chronic inflammation and tissue injury. We have previously identified several pathways that regulate the activity of NADPH oxidase in human monocytes; however, the receptor(s) responsible for the activation of NADPH oxidase in primary human monocytes have not yet been determined. This dissertation shows that pattern recognition receptors, namely Dectin-1, is essential for regulating NADPH oxidase activity in Zymosan-activated human monocytes. In addition this book focuses on Dectin-1 downstream signaling and complex formation with intracellular signaling proteins.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Activation of the NADPH oxidase enzyme complex results in the production of the oxygen free radical, superoxide anion (O2.-). Superoxide anion is critical for host defense against fungal and bacterial pathogens and efficient immune responses; however, uncontrolled monocyte-derived O2.- may contribute to chronic inflammation and tissue injury. We have previously identified several pathways that regulate the activity of NADPH oxidase in human monocytes; however, the receptor(s) responsible for the activation of NADPH oxidase in primary human monocytes have not yet been determined. This dissertation shows that pattern recognition receptors, namely Dectin-1, is essential for regulating NADPH oxidase activity in Zymosan-activated human monocytes. In addition this book focuses on Dectin-1 downstream signaling and complex formation with intracellular signaling proteins.

Biographie de l'auteur

Deena Elsori received her PhD in Regulatory and Cell Biology from Cleveland State University and the Cleveland Clinic in 2009. As an Assistant Professor of Biology at Abu Dhabi University (UAE),Deena is responsible for designing and teaching different biology courses.She is also the coordinator of the Public Health program at ADU.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848418134
ISBN 13 
9783848418138
Reliure
Broché
Nombre de pages
76
Coordonnées du fabricant
non disponible
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