Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment - Couverture souple

Tiwari, Gaurav; Tiwari, Ruchi; Bhati, Lokesh

 
9783848419500: Preparation and Solid-State Characterization of Leflunomide Polymorph: Tiwari et al. leflunomide polymorph along with its solubility assessment
Couverture souple
ISBN 10 : 3848419505 ISBN 13 : 9783848419500
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I,II,III,IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form II tablets showed a significant improvement in terms of dissolution rate, drug release and solubility.

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Présentation de l'éditeur

Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I,II,III,IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form II tablets showed a significant improvement in terms of dissolution rate, drug release and solubility.

Biographie de l'auteur

Dr. Gaurav Tiwari (Assistant Professor) in the institute of Pharmacy, PSIT, Kanpur. He did his M.Pharm from Uttar Pradesh Technical University, Uttar Pradesh and Ph.D from Jaipur National University, Jaipur. He has five years of teaching experience and three year research experience, having more than 45 national and international publications.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848419505
ISBN 13 
9783848419500
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
Personne responsable
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