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Analysis of Some Phosphorus Containing Compounds in Pharmaceuticals: Analytical Determination of Alendronate, Etidronate and Risedronate in Drug Substance and Pharmaceutical Preparations - Couverture souple

El-Shaheny, Rania; Walash, Mohamed; Eid, Manal

 
9783848422753: Analysis of Some Phosphorus Containing Compounds in Pharmaceuticals: Analytical Determination of Alendronate, Etidronate and Risedronate in Drug Substance and Pharmaceutical Preparations
Couverture souple
ISBN 10 : 3848422751 ISBN 13 : 9783848422753
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Among phosphorus containing pharmaceutical compounds, bisphosphonates is a very important class. Therapeutic uses of bisphosphonates include maagement of malignancy-associated hypercalcemia, treatment of postmenopausal osteoporosis and cancer. Bisphosphonates, as a group of active pharmaceutical compounds, generally "give headache" to analytical chemists. The two phosphonic groups per molecule lend a strongly ionic character and increased polarity to these compounds. Additionally, the majority of the members of this family lacks of chromophores, or even has a weak one, excluding convenient sensitive UV or fluorescence detection.This work is devoted to the determination of three bisphosphonate drugs commercially available in the local Egyptian market (alendronate, etidronate and risedronate.The usefulness of different spectrophotometric and chromatographic methods was exploited.The proposed methods are of great value in quality control analysis of the studied compounds owing to their improved simplicity, sensitivity, low-cost, and its independence on expensive instruments, or critical analytical reagents.

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Présentation de l'éditeur

Among phosphorus containing pharmaceutical compounds, bisphosphonates is a very important class. Therapeutic uses of bisphosphonates include maagement of malignancy-associated hypercalcemia, treatment of postmenopausal osteoporosis and cancer. Bisphosphonates, as a group of active pharmaceutical compounds, generally "give headache" to analytical chemists. The two phosphonic groups per molecule lend a strongly ionic character and increased polarity to these compounds. Additionally, the majority of the members of this family lacks of chromophores, or even has a weak one, excluding convenient sensitive UV or fluorescence detection.This work is devoted to the determination of three bisphosphonate drugs commercially available in the local Egyptian market (alendronate, etidronate and risedronate.The usefulness of different spectrophotometric and chromatographic methods was exploited.The proposed methods are of great value in quality control analysis of the studied compounds owing to their improved simplicity, sensitivity, low-cost, and its independence on expensive instruments, or critical analytical reagents.

Biographie de l'auteur

Dr. Rania El-Shaheny is a lecturer in Department of Analytical chemistry, Faculty of Pharmacy, Mansoura University, Egypt. She received MSc and PhD in Analytical Chemistry from Fcaulty of Pharmacy, Mansoura University. Her research interests include pharmaceutical analysis, quality control, stability studies of drugs and therapeutic drug monitoring.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848422751
ISBN 13 
9783848422753
Reliure
Broché
Nombre de pages
188
Coordonnées du fabricant
non disponible
Personne responsable
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