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New Amphiphiles Functionalized with Oligo and Olysaccharides: Preparation and characterization of new amphiphiles Functionalized with Oligo- and Polysaccharides - Couverture souple

Gonçalves Dal-Bo, Alexandre; Fort, Sébastien; Borsali, Redouane

 
9783848425648: New Amphiphiles Functionalized with Oligo and Olysaccharides: Preparation and characterization of new amphiphiles Functionalized with Oligo- and Polysaccharides
Couverture souple
ISBN 10 : 3848425645 ISBN 13 : 9783848425648
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

This book reports the preparation and characterization of new rod-coil amphiphiles functionalized with oligo- and polysaccharides through Huisgen 1,3-dipolar cycloaddition reactions between species functionalized by an azide group on one side and an terminal alkyne on the other catalyzed by copper. The amphiphiles were synthesized and characterized based on different hydrophobic parts conjugated with the polymer poly(ethylene oxide) PEO with a hydrophilic spacer arm and the oligo- and polyssaccharides 2-propargyl-2-acetamido- 2-deoxy-β-D-glucopyranose (GlcNAc) and propargyl β-D-galactopyranosyl-(1-4)-β-D-glucopyranose (Lac). The amphiphiles synthesized were characterized in terms of their chemical structure and composition through nuclear magnetic resonance (NMR),mass spectroscopy (MALDI-TOF-MS and ESI-MS)and high resolution mass spectroscopy (HRMS). After the dissolution in water, the amphiphiles self-associate in highly regular micelles with an average diameter of 2RH~10nm. Dynamic light scattering (DLS), transmission electron microscopy (TEM) and small angle x-ray scattering (SAXS) were used in order to investigate the structure and dynamics of these saccharide amphiphiles.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book reports the preparation and characterization of new rod-coil amphiphiles functionalized with oligo- and polysaccharides through Huisgen 1,3-dipolar cycloaddition reactions between species functionalized by an azide group on one side and an terminal alkyne on the other catalyzed by copper. The amphiphiles were synthesized and characterized based on different hydrophobic parts conjugated with the polymer poly(ethylene oxide) PEO with a hydrophilic spacer arm and the oligo- and polyssaccharides 2-propargyl-2-acetamido- 2-deoxy-β-D-glucopyranose (GlcNAc) and propargyl β-D-galactopyranosyl-(1-4)-β-D-glucopyranose (Lac). The amphiphiles synthesized were characterized in terms of their chemical structure and composition through nuclear magnetic resonance (NMR),mass spectroscopy (MALDI-TOF-MS and ESI-MS)and high resolution mass spectroscopy (HRMS). After the dissolution in water, the amphiphiles self-associate in highly regular micelles with an average diameter of 2RH~10nm. Dynamic light scattering (DLS), transmission electron microscopy (TEM) and small angle x-ray scattering (SAXS) were used in order to investigate the structure and dynamics of these saccharide amphiphiles.

Biographie de l'auteur

Alexandre G Dal-Bó Born 15/11/1981 Criciuma, Brazil.2011-2012 Postdoctorate in Biomaterials – Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil,2011 Doctorate in Chemistry, Universidade Federal de Santa Catarina, UFSC, Florianopolis, Brazil and Université Joseph Fourier Grenoble France,2007 Master's in Chemistry UFSC.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848425645
ISBN 13 
9783848425648
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
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