Articles liés à Chitosan-based heart valve with improved mechanical...

Chitosan-based heart valve with improved mechanical properties: A tissue engineering approach - Couverture souple

Albanna, Mohammad

 
9783848436736: Chitosan-based heart valve with improved mechanical properties: A tissue engineering approach
Couverture souple
ISBN 10 : 3848436736 ISBN 13 : 9783848436736
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Chitosan is being widely studied for tissue engineering applications due to its biocompatibility and biodegradability.However, its use in load-bearing applications is limited due to moderate to low mechanical properties.In this work,we investigated the effectiveness of a fiber reinforcement method for enhancing the mechanical properties of chitosan scaffolds.The results showed that incorporating fibers improved scaffold strength and stiffness in proportion to the fiber/scaffold mass ratio.A fiber-reinforced heart valve leaflet scaffold achieved strength values comparable to the radial values of human pulmonary and aortic valves.Various chemical and physical treatments were studied to improve the mechanical properties of chitosan fibers.With combination of chemical and physical treatments, fiber stiffness improved 40fold compared to unmodified fibers.Utility of isolated ovine bone marrow-derived MSCs was evaluated for cardiovascular tissue engineering applications. The effect of various glycosaminoglycans (GAGs) on MSCs morphology and proliferation was evaluated. Lastly, studies showed that MSCs proliferation improved in proportion to fiber stiffness.

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Présentation de l'éditeur

Chitosan is being widely studied for tissue engineering applications due to its biocompatibility and biodegradability.However, its use in load-bearing applications is limited due to moderate to low mechanical properties.In this work,we investigated the effectiveness of a fiber reinforcement method for enhancing the mechanical properties of chitosan scaffolds.The results showed that incorporating fibers improved scaffold strength and stiffness in proportion to the fiber/scaffold mass ratio.A fiber-reinforced heart valve leaflet scaffold achieved strength values comparable to the radial values of human pulmonary and aortic valves.Various chemical and physical treatments were studied to improve the mechanical properties of chitosan fibers.With combination of chemical and physical treatments, fiber stiffness improved 40fold compared to unmodified fibers.Utility of isolated ovine bone marrow-derived MSCs was evaluated for cardiovascular tissue engineering applications. The effect of various glycosaminoglycans (GAGs) on MSCs morphology and proliferation was evaluated. Lastly, studies showed that MSCs proliferation improved in proportion to fiber stiffness.

Biographie de l'auteur

Mohammad Albanna received his PhD from Wayne State University in Biomedical Engineering (BME) with focus on heart valve tissue engineering. Dr. Albanna holds 2 master degrees in BME & Electrical and Computer Engineering (ECE). He is currently working as a research scientist and skin team leader at Wake Forest Institute for Regenerative Medicine.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848436736
ISBN 13 
9783848436736
Reliure
Broché
Nombre de pages
140
Coordonnées du fabricant
non disponible
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