Detection of Translocation t(11;18) by FISH in GIT MALT Lymphomas: Pathological and Immunohistochemical Study of Gastrointestinal Lymphomas - Couverture souple

Talaat, Iman Mamdouh; Mashali, Nagwa; El-Sheikh, Samar

 
9783848440771: Detection of Translocation t(11;18) by FISH in GIT MALT Lymphomas: Pathological and Immunohistochemical Study of Gastrointestinal Lymphomas
Couverture souple
ISBN 10 : 3848440776 ISBN 13 : 9783848440771
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Lymphoma is a neoplasm of the immune system cells and their precursors. Despite their common origin from bone marrow, these tumors exhibit a wide range of immunological and genetic characteristics, which reflect the diversity of their normal counterpart cells. Lymphoid malignancies arise from both B and T cell compartments of the immune system. The cytogenetic analysis of lymphomas is hampered by the low yield and poor quality of metaphase spreads. More recently however, the application of techniques such as FISH and PCR, for which culturing of tumor cells is not a pre-requisite, has improved the characterization of lymphomas at the genetic level. Chromosomal translocations have an established role in diagnosis, prognosis, and prediction of response to treatment in haematologic and lymphoid malignancies. FISH, the assay of choice for localization of specific nucleic acids sequences in native context, is a 20-year-old technology that has developed continuously. Over its maturation, various methodologies and modifications have been introduced to optimize the detection of DNA and RNA.

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Présentation de l'éditeur

Lymphoma is a neoplasm of the immune system cells and their precursors. Despite their common origin from bone marrow, these tumors exhibit a wide range of immunological and genetic characteristics, which reflect the diversity of their normal counterpart cells. Lymphoid malignancies arise from both B and T cell compartments of the immune system. The cytogenetic analysis of lymphomas is hampered by the low yield and poor quality of metaphase spreads. More recently however, the application of techniques such as FISH and PCR, for which culturing of tumor cells is not a pre-requisite, has improved the characterization of lymphomas at the genetic level. Chromosomal translocations have an established role in diagnosis, prognosis, and prediction of response to treatment in haematologic and lymphoid malignancies. FISH, the assay of choice for localization of specific nucleic acids sequences in native context, is a 20-year-old technology that has developed continuously. Over its maturation, various methodologies and modifications have been introduced to optimize the detection of DNA and RNA.

Biographie de l'auteur

M.B.B.CH, MSc, PhD.Lecturer of Pathology, Faculty of Medicine, University of Alexandria, Egypt.Member of the International Academy of Pathology (Arab division), of the Egyptian Society of Pathology and of the Pediatric Oncology Board (University of Alexandria).

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848440776
ISBN 13 
9783848440771
Reliure
Broché
Nombre de pages
204
Coordonnées du fabricant
non disponible
Personne responsable
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