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Bio Equivalence Study of Some Antidepressant Drugs: Using LC-MS/MS Technique - Couverture souple

Shah, Sanjay; Bhatt, Mitesh

 
9783848447145: Bio Equivalence Study of Some Antidepressant Drugs: Using LC-MS/MS Technique
Couverture souple
ISBN 10 : 3848447142 ISBN 13 : 9783848447145
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Drug analysis is important in several phases of pharmaceutical development, such as stability studies, formulation and quality control. Several techniques have been employed in the development of analytical methods for drug quantification in both biological fluids and dosage forms. The latter is the simplest kind of sample due to its high analyte content and few matrix effects, so a large number of techniques and methods are suitable for drug quantification in dosage forms. The bioanalytical methods for the determination of some antidepressant drugs are quantified in biological matrix. In this book, the development and validation of UPLC-MS/MS methods for the quantification of some antidepressant drugs (paroxetine, amitriptyline and its metabolite) in human plasma are described. All the developed methods were found selective, sensitive and rapid. They have simple extraction procedure and a short run time. They were also found suitable for clinical pharmacokinetics studies in healthy human volunteers following oral administrations.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Drug analysis is important in several phases of pharmaceutical development, such as stability studies, formulation and quality control. Several techniques have been employed in the development of analytical methods for drug quantification in both biological fluids and dosage forms. The latter is the simplest kind of sample due to its high analyte content and few matrix effects, so a large number of techniques and methods are suitable for drug quantification in dosage forms. The bioanalytical methods for the determination of some antidepressant drugs are quantified in biological matrix. In this book, the development and validation of UPLC-MS/MS methods for the quantification of some antidepressant drugs (paroxetine, amitriptyline and its metabolite) in human plasma are described. All the developed methods were found selective, sensitive and rapid. They have simple extraction procedure and a short run time. They were also found suitable for clinical pharmacokinetics studies in healthy human volunteers following oral administrations.

Biographie de l'auteur

Dr Sanjay Shah is an eminent researcher & Principal of Pilvai Sc College,INDIA.He is the author of several books and research papers published in reputed journals. He guided 9 PhD students.Dr Mitesh Bhatt has obtained his PhD degree in analytical chemistry. He has worked in various research projects. He published several papers in reputed journals

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848447142
ISBN 13 
9783848447145
Reliure
Broché
Nombre de pages
156
Coordonnées du fabricant
non disponible
Personne responsable
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