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Studies Towards the Synthesis of (–)-Ebelactone-A and (–)-Maurenone: Studies Directed Towards the Total Synthesis of Polypropionate Natural Products (–)-Ebelactone-A and (–)-Maurenone - Couverture souple

Kontham, Ravindar; Yadav, Jhillu Singh

 
9783848449583: Studies Towards the Synthesis of (–)-Ebelactone-A and (–)-Maurenone: Studies Directed Towards the Total Synthesis of Polypropionate Natural Products (–)-Ebelactone-A and (–)-Maurenone
Couverture souple
ISBN 10 : 3848449587 ISBN 13 : 9783848449583
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. (–)-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterase’s, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique and challenging structure of Ebelactone, made this compound an exciting target for the total synthesis. Secondly, this book described an efficient synthetic protocol for polypropionate natural product (-)-Maurenone, which was isolated by Faulkner et al. in 1986 from specimens of the pulmonate mollusc Siphonaria maura. This monograph is unique in dealing with many interesting synthetic protocols including full experimental procedures, analytical data for all synthetic materials and complete reference sections. This monograph can be served as a good hand book for synthetic organic chemists.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. (–)-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterase’s, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique and challenging structure of Ebelactone, made this compound an exciting target for the total synthesis. Secondly, this book described an efficient synthetic protocol for polypropionate natural product (-)-Maurenone, which was isolated by Faulkner et al. in 1986 from specimens of the pulmonate mollusc Siphonaria maura. This monograph is unique in dealing with many interesting synthetic protocols including full experimental procedures, analytical data for all synthetic materials and complete reference sections. This monograph can be served as a good hand book for synthetic organic chemists.

Biographie de l'auteur

Ravindar Kontham was born in Ashalapally-Warangal, India in 1978. He completed BSc, PhD from Kakatiya University & M.Sc from Osmania University, India. Completed his PhD under the guidance of Dr. J. S. Yadav, Director, CSIR-IICT, Hyderabad, India. Currently he is a post-doctoral fellow with Prof. Pierre Deslongchamps, University Laval, QC, Canada.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848449587
ISBN 13 
9783848449583
Reliure
Broché
Nombre de pages
164
Coordonnées du fabricant
non disponible
Personne responsable
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