Bioadhesive Drug Delivery System For a Cardiovascular Drug: An Approach using Progressive Hydration Technology - Couverture souple

Srinivasan, Ganga; Gaud, R. S.; Gupta, Amit

 
9783848481859: Bioadhesive Drug Delivery System For a Cardiovascular Drug: An Approach using Progressive Hydration Technology
Couverture souple
ISBN 10 : 3848481855 ISBN 13 : 9783848481859
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Market for advanced drug delivery systems has undergone a period of innovation and significant expansion over the past decade.In this context worldwide market for transmucosal products is in excess of five billion annually and is expected to continue to grow at a rapid pace.Hence transmucosal drug delivery holds lot of promise in the coming era. Amongst various transmucosal routes buccal region of the oral cavity has got optimal attributes for transmucosal and modified drug delivery and has lot of promise and commercial viability.Present work encompasses development of extended release formulation of an antihypertensive drug Nisoldipine using bioadhesive polymers, to improve the bioavailability along with minimal variation in the therapeutic response. Nisoldipine is a calcium channel blocker of the dihydropyridine class. Nisoldipine is an ideal candidate for this work as its bioavailability is 4-8% and has high inter and intrasubject variability in response.Studies include formulation development using Progressive Hydration Technology, optimizing and validating the formulation approaches, stability studies and in-vivo evaluation in rabbits.

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Présentation de l'éditeur

Market for advanced drug delivery systems has undergone a period of innovation and significant expansion over the past decade.In this context worldwide market for transmucosal products is in excess of five billion annually and is expected to continue to grow at a rapid pace.Hence transmucosal drug delivery holds lot of promise in the coming era. Amongst various transmucosal routes buccal region of the oral cavity has got optimal attributes for transmucosal and modified drug delivery and has lot of promise and commercial viability.Present work encompasses development of extended release formulation of an antihypertensive drug Nisoldipine using bioadhesive polymers, to improve the bioavailability along with minimal variation in the therapeutic response. Nisoldipine is a calcium channel blocker of the dihydropyridine class. Nisoldipine is an ideal candidate for this work as its bioavailability is 4-8% and has high inter and intrasubject variability in response.Studies include formulation development using Progressive Hydration Technology, optimizing and validating the formulation approaches, stability studies and in-vivo evaluation in rabbits.

Biographie de l'auteur

Dr Ganga Srinivasan is a Professor in Pharmaceutics at VES College of Pharmacy, Mumbai, India.She is an alumunus of Banaras Hindu University and has 19 years of post Ph.D experience in academics and research. She has several publications to her credit in national and international journals.Work areas include Oral, Buccal and Implantable DDS.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848481855
ISBN 13 
9783848481859
Reliure
Broché
Nombre de pages
164
Coordonnées du fabricant
non disponible
Personne responsable
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