Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS: Dissolution media with colonic probiotics - Couverture souple

Kotla, Niranjan Goud ; Y., Yashwant ; Shivapooja, Ashwini

9783848482870: Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS: Dissolution media with colonic probiotics

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ISBN 10 : 3848482878 ISBN 13 : 9783848482870

Editeur : LAP LAMBERT Academic Publishing, 2014

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Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade “A” honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery.

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2014
Langue: anglais
ISBN 10: 3848482878
ISBN 13: 9783848482870
Reliure: Broch�
Nombre de pages: 96
Coordonn�es du fabricant: non disponible
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Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS

Niranjan Goud Kotla

Edit� par LAP LAMBERT Academic Publishing Feb 2014, 2014

ISBN 10 : 3848482878 ISBN 13 : 9783848482870

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade 'A' honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery. 96 pp. Englisch. N� de r�f. du vendeur 9783848482870

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Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS

Niranjan Goud Kotla|Yashwant Y.|Ashwini Shivapooja

Edit� par LAP LAMBERT Academic Publishing, 2014

ISBN 10 : 3848482878 ISBN 13 : 9783848482870

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Kotla Niranjan GoudNiranjan Goud Kotla,research scholar in pharmaceutical segment, completed B. Pharmacy from Osmania University, Hyderabad and M. Pharmacy from LPU, Punjab. My vital area of research is targeted drug delivery, dissol. N� de r�f. du vendeur 5526033

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Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS

Niranjan Goud Kotla

Edit� par LAP LAMBERT Academic Publishing Feb 2014, 2014

ISBN 10 : 3848482878 ISBN 13 : 9783848482870

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade 'A' honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 96 pp. Englisch. N� de r�f. du vendeur 9783848482870

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Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS : Dissolution media with colonic probiotics

Niranjan Goud Kotla

Edit� par LAP LAMBERT Academic Publishing, 2014

ISBN 10 : 3848482878 ISBN 13 : 9783848482870

Neuf Taschenbuch

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Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade 'A' honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery. N� de r�f. du vendeur 9783848482870

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