Insilico study of Type II Diabetes and Effective drugs: A Bioinformatics study of Diabetes genes - Couverture souple

Guttula, Satyavani

 
9783848483204: Insilico study of Type II Diabetes and Effective drugs: A Bioinformatics study of Diabetes genes
Couverture souple
ISBN 10 : 3848483203 ISBN 13 : 9783848483204
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Diabetes is an important and increasingly common global health problem. The World Health Organization has estimated that about 170 million people currently have diabetes worldwide.Environmental factors such as obesity, a diet high in sugar, and a sedentary lifestyle are all risk factors for developing Type 2 diabetes. This book provides the basic knowledge to analyze Microarray data of diebetes. Clustering is done to the genes which are more expressed in Type II diabetes. Phylogenetic analysis is done on the basis of the sequence similarity by which the rate of expression is also similar. Two proteins Beliverdine and Uroporphyrinogen are taken and eight antidiabetic drugs such as Acarbose, Gliquidone, Metformin, Miglitol, Mitiglinide, Pioglitazone, Sitagliptin, Voglibose. These drugs are used as ligands. The two receptors are subjected to docking with eight ligands. ACARBOSE is determined as most efficient drug.

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Présentation de l'éditeur

Diabetes is an important and increasingly common global health problem. The World Health Organization has estimated that about 170 million people currently have diabetes worldwide.Environmental factors such as obesity, a diet high in sugar, and a sedentary lifestyle are all risk factors for developing Type 2 diabetes. This book provides the basic knowledge to analyze Microarray data of diebetes. Clustering is done to the genes which are more expressed in Type II diabetes. Phylogenetic analysis is done on the basis of the sequence similarity by which the rate of expression is also similar. Two proteins Beliverdine and Uroporphyrinogen are taken and eight antidiabetic drugs such as Acarbose, Gliquidone, Metformin, Miglitol, Mitiglinide, Pioglitazone, Sitagliptin, Voglibose. These drugs are used as ligands. The two receptors are subjected to docking with eight ligands. ACARBOSE is determined as most efficient drug.

Biographie de l'auteur

Dr.Guttula.Satyavani,Professor & Head (Bioinformatics),Department Of Biotechnology,Al-Ameer College of Engineering & IT,Gudilova,Anandapuram,Visakhapatnam-531173Andhra Pradesh,India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848483203
ISBN 13 
9783848483204
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
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