Postmenopausal Coronary Artery Disease Risk: Endothelial & Platelet Dysfunction with Possible Role of Glu298Asp eNOS Gene Polymorphism - Couverture souple

Dabla, Pradeep Kumar; Bhattacharjee, Jayashree; Dabla, Vandana

 
9783848484201: Postmenopausal Coronary Artery Disease Risk: Endothelial & Platelet Dysfunction with Possible Role of Glu298Asp eNOS Gene Polymorphism
Couverture souple
ISBN 10 : 384848420X ISBN 13 : 9783848484201
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Menopause increases the risk for women independent of age. Prior to menopause, the risk of Coronary Artery Disease (CAD) for women lags behind the risk for men. After menopause, women have similar risks of CAD as men of the same age. The functional and morphological alteration in endothelial cells is critical to atherosclerotic process. After menopause, marked decline in Estrogen and Nitric Oxide (NO) levels takes place. Estrogen exerts its various CAD protective actions by arterial endothelium sex steroid receptors. Nitric oxide released from vascular endothelium is one of most known versatile molecules and has a role in almost every biological system. Nitric oxide inhibits various key steps in development of atherosclerosis via inhibition of platelet activity and smooth muscle cell proliferation. Further presence of Endothelial Nitric Oxide Synthase (eNOS) gene polymorphism Glu298Asp may provide additional insult by decreasing NO levels adding to the CAD risk. Hence, postmenopausal women those who presents with eNOS Glu298Asp polymorphic gene may have higher CAD risk.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Menopause increases the risk for women independent of age. Prior to menopause, the risk of Coronary Artery Disease (CAD) for women lags behind the risk for men. After menopause, women have similar risks of CAD as men of the same age. The functional and morphological alteration in endothelial cells is critical to atherosclerotic process. After menopause, marked decline in Estrogen and Nitric Oxide (NO) levels takes place. Estrogen exerts its various CAD protective actions by arterial endothelium sex steroid receptors. Nitric oxide released from vascular endothelium is one of most known versatile molecules and has a role in almost every biological system. Nitric oxide inhibits various key steps in development of atherosclerosis via inhibition of platelet activity and smooth muscle cell proliferation. Further presence of Endothelial Nitric Oxide Synthase (eNOS) gene polymorphism Glu298Asp may provide additional insult by decreasing NO levels adding to the CAD risk. Hence, postmenopausal women those who presents with eNOS Glu298Asp polymorphic gene may have higher CAD risk.

Biographie de l'auteur

Dr. Pradeep has obtained his MD Biochemistry from Lady Hardinge Medical College, Delhi, India in 2007. He has been awarded many times for his research in “Postmenopausal Women CAD Risk”. Dr. Jayashree has supervised the role of Nitric Oxide in various diseases extensively. Vandana Dabla has expertise in Total Quality Management and Statistics.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
384848420X
ISBN 13 
9783848484201
Reliure
Broché
Nombre de pages
108
Coordonnées du fabricant
non disponible
Personne responsable
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