Solubility enhancement of diacerin using cyclodextrin: Solubility and evalution of diacerein using cyclodextrin as hydrophillic carriers - Couverture souple

Patrekar, Prasad; Dalvi, Vishal; Patil, Chandrakant

 
9783848486458: Solubility enhancement of diacerin using cyclodextrin: Solubility and evalution of diacerein using cyclodextrin as hydrophillic carriers
Couverture souple
ISBN 10 : 3848486458 ISBN 13 : 9783848486458
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Cyclorins, hydrophilic carriers, are cyclic polysaccharides which have property of forming inclusion complex with various guest molecules with suitable polarity and dimensions. They have been used extensively for solubility enhancement of hydrophobic drug/water insoluble drugs. Diacerein is anthraquinone compound designed to treatment of osteoarthritis. The purpose of this research was to enhance the solubility and therefore dissolution of Diacerein by complexation with β-cyclodextrin (βCD) and hydroxyl propyl β-cyclodextrin (HP βCD).This study represents the formulation of inclusion complex with βCD and HP βCD by kneading method and their characterization and evaluation of improvement in dissolution profile. Inclusion complex compared to pure drug and physical mixtures, remarkable enhancement in invitro drug release profile in PH 6.8 phosphate buffer was obtained in both inclusion complexes of βCD and HP βCD, especially with HP βCD. Complexation of Diacerein with hydrophilic carriers like βCD and HP βCD offers a major enhancement in drug solubility.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Cyclorins, hydrophilic carriers, are cyclic polysaccharides which have property of forming inclusion complex with various guest molecules with suitable polarity and dimensions. They have been used extensively for solubility enhancement of hydrophobic drug/water insoluble drugs. Diacerein is anthraquinone compound designed to treatment of osteoarthritis. The purpose of this research was to enhance the solubility and therefore dissolution of Diacerein by complexation with β-cyclodextrin (βCD) and hydroxyl propyl β-cyclodextrin (HP βCD).This study represents the formulation of inclusion complex with βCD and HP βCD by kneading method and their characterization and evaluation of improvement in dissolution profile. Inclusion complex compared to pure drug and physical mixtures, remarkable enhancement in invitro drug release profile in PH 6.8 phosphate buffer was obtained in both inclusion complexes of βCD and HP βCD, especially with HP βCD. Complexation of Diacerein with hydrophilic carriers like βCD and HP βCD offers a major enhancement in drug solubility.

Biographie de l'auteur

Mr. Prasad Patrekar has successfully completed M. Pharm in Pharmaceutics.He has also completed post graduate degree in management studies. He is having a blend of experience in teaching and industry. He has also published several articles in reputed journals. Presently he is working as Principal at Adarsh Institute of Pharmacy.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848486458
ISBN 13 
9783848486458
Reliure
Broché
Nombre de pages
84
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne