Memory cells in diabetes: The effect of hyperglycemic memory on T- cells function - Couverture souple

Salman, Mohammed Ali; Sultan, Baqur A.; AL-Mosawi, Jaafar K.

 
9783848490752: Memory cells in diabetes: The effect of hyperglycemic memory on T- cells function
Couverture souple
ISBN 10 : 3848490757 ISBN 13 : 9783848490752
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Antigen exposure is a strong stimulator of lymphocytes that triggers a variety of events including formation of cytokines such as interferon (IFN)-gamma (Cantrell, 1996), the defense against pathogen is impaired at high ambient osmolarity such as in the hyperosmolar renal medulla. Moreover, the immune response was reported to be impaired in diabetes Mellitus, which typically leads to increase of extracellular osmolarity,It cannot be excluded that "hyperglycemic memory" confounds the relationship between cell function and concomitant blood glucose concentration, i.e., hyperglycemia-induced changes in gene expression and biological reactions such as advanced glycation-end products in long-lived macromolecules may not be reversed when glycemia returns to normal, so that poor control is progressively "imprinted" on the cells , resulting in impairment of cellular immune activity.

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Présentation de l'éditeur

Antigen exposure is a strong stimulator of lymphocytes that triggers a variety of events including formation of cytokines such as interferon (IFN)-gamma (Cantrell, 1996), the defense against pathogen is impaired at high ambient osmolarity such as in the hyperosmolar renal medulla. Moreover, the immune response was reported to be impaired in diabetes Mellitus, which typically leads to increase of extracellular osmolarity,It cannot be excluded that "hyperglycemic memory" confounds the relationship between cell function and concomitant blood glucose concentration, i.e., hyperglycemia-induced changes in gene expression and biological reactions such as advanced glycation-end products in long-lived macromolecules may not be reversed when glycemia returns to normal, so that poor control is progressively "imprinted" on the cells , resulting in impairment of cellular immune activity.

Biographie de l'auteur

Dr.Mohammed Ali S. Al-Kaaby,MBCHB(MD),MSc.Clinical Immunology/department of Pathology and Foreinsic Medicine/Medical college/Wasit University,Iraq.graduated from Medical College al-kufa Un.in 2003/iraq,finished Masterdegree in Medical Microbiology/Clinical Immunology in 2010 same collegeteaching in Medical College/Wasit Un/Iraq.preparing my PHd

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848490757
ISBN 13 
9783848490752
Reliure
Broché
Nombre de pages
96
Coordonnées du fabricant
non disponible
Personne responsable
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