Enhancement of complexation of drug: binary and ternary mixtures: Bhati et al. enhancement of complexation - Couverture souple

Bhati, Lokesh Kumar; Bhati, Meena; Tiwari, Gaurav

 
9783848493906: Enhancement of complexation of drug: binary and ternary mixtures: Bhati et al. enhancement of complexation
Couverture souple
ISBN 10 : 384849390X ISBN 13 : 9783848493906
Editeur : LAP Lambert Academic Publishing, 2012

Synopsis

The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HPβ-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HPβ-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HPβ-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HPβ-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.

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À propos de l?auteur

Lokesh bhati is presently a research scientist in mankind research laboratory, gurgaon, India. He is presently the reviewer of many indexed journals. He has many publications in national and international journals.He has five years of research experience in controlled and targetted drug delivery.

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Éditeur
LAP Lambert Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
384849390X
ISBN 13 
9783848493906
Reliure
Broché
Nombre de pages
120
Coordonnées du fabricant
non disponible
Personne responsable
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