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Enhancement of complexation of drug: binary and ternary mixtures: Bhati et al. enhancement of complexation - Couverture souple
Synopsis
The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HPβ-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HPβ-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HPβ-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HPβ-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.
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À propos de l?auteur
Lokesh bhati is presently a research scientist in mankind research laboratory, gurgaon, India. He is presently the reviewer of many indexed journals. He has many publications in national and international journals.He has five years of research experience in controlled and targetted drug delivery.
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- ÉditeurLAP Lambert Academic Publishing
- Date d'édition2012
- ISBN 10 384849390X
- ISBN 13 9783848493906
- ReliureBroché
- Langueanglais
- Nombre de pages120
- Coordonnées du fabricantnon disponible
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Enhancement of complexation of drug: binary and ternary mixtures
Edité par
LAP LAMBERT Academic Publishing, 2012
ISBN 10 : 384849390X
ISBN 13 : 9783848493906
Neuf
Couverture souple
Vendeur : moluna, Greven, Allemagne
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Bhati Lokesh KumarLokesh bhati is presently a research scientist in mankind research laboratory, gurgaon, India. He is presently the reviewer of many indexed journals. He has many publications in national and international journals.H. N° de réf. du vendeur 5526893
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Enhancement of complexation of drug: binary and ternary mixtures : Bhati et al. enhancement of complexation
Edité par
LAP LAMBERT Academic Publishing, 2012
ISBN 10 : 384849390X
ISBN 13 : 9783848493906
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP -CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP -CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP -CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP -CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability. N° de réf. du vendeur 9783848493906
Quantité disponible : 1 disponible(s)
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Enhancement of complexation of drug: binary and ternary mixtures
Edité par
LAP LAMBERT Academic Publishing Apr 2012, 2012
ISBN 10 : 384849390X
ISBN 13 : 9783848493906
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP -CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP -CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP -CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP -CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability. 120 pp. Englisch. N° de réf. du vendeur 9783848493906
Quantité disponible : 2 disponible(s)
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Enhancement of complexation of drug: binary and ternary mixtures
Edité par
LAP LAMBERT Academic Publishing Apr 2012, 2012
ISBN 10 : 384849390X
ISBN 13 : 9783848493906
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Neuware -The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP¿-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP¿-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP¿-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP¿-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.Books on Demand GmbH, Überseering 33, 22297 Hamburg 120 pp. Englisch. N° de réf. du vendeur 9783848493906
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Enhancement of complexation of drug: binary and ternary mixtures: Bhati et al. enhancement of complexation
Edité par
LAP LAMBERT Academic Publishing, 2012
ISBN 10 : 384849390X
ISBN 13 : 9783848493906
Ancien ou d'occasion
Paperback
Vendeur : Mispah books, Redhill, SURRE, Royaume-Uni
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Paperback. Etat : Like New. Like New. book. N° de réf. du vendeur ERICA796384849390X6
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