Reproductive Toxicology: Effects of Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees on Male Reproductive Functions in Rats - Couverture souple

Mohd Dasuki, Sul'ain; Syed Mohsin, .; Hasnan, .

 
9783848496785: Reproductive Toxicology: Effects of Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees on Male Reproductive Functions in Rats
Couverture souple
ISBN 10 : 384849678X ISBN 13 : 9783848496785
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Andrographis paniculata (AP) has selected to be developed as an anti-diabetic herbal extract. However, the adverse effect of AP on male reproductive function is still unknown. The present study aims to look at the effects of 50% AP ethanolic extract (APE) on the male Sprague Dawley rats’ reproductive functions and to see whether it has anti-fertility effects. Four important endpoints were observed i.e. male reproductive performance (MRP), male sexual behavior (MSB), histological toxicity evaluation of male reproductive organs and hormonal level. Sixty adult male rats aged 8-10 weeks were used in this study. Five groups were administered with APE at doses of 0.5, 1.0, 10, 100 and 1000 mg/kg for not less than 77 days by oral gavaging. MRP remained unaffected and no toxicity effects were observed. The treatment of APE of up to 1000mg/kg neither induce any significant changes in sexual behavioral parameters nor changes of body, reproductive organs and other internal organs weights. APE treatment effect showed no anti-fertility or toxic effects to male reproductive functions. APE seems, therefore, to be safe for rats.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Andrographis paniculata (AP) has selected to be developed as an anti-diabetic herbal extract. However, the adverse effect of AP on male reproductive function is still unknown. The present study aims to look at the effects of 50% AP ethanolic extract (APE) on the male Sprague Dawley rats’ reproductive functions and to see whether it has anti-fertility effects. Four important endpoints were observed i.e. male reproductive performance (MRP), male sexual behavior (MSB), histological toxicity evaluation of male reproductive organs and hormonal level. Sixty adult male rats aged 8-10 weeks were used in this study. Five groups were administered with APE at doses of 0.5, 1.0, 10, 100 and 1000 mg/kg for not less than 77 days by oral gavaging. MRP remained unaffected and no toxicity effects were observed. The treatment of APE of up to 1000mg/kg neither induce any significant changes in sexual behavioral parameters nor changes of body, reproductive organs and other internal organs weights. APE treatment effect showed no anti-fertility or toxic effects to male reproductive functions. APE seems, therefore, to be safe for rats.

Biographie de l'auteur

Mohd Dasuki Sul'ain graduated for PhD(Pharmacology/Toxicology),USM, Malaysia(2007)and Certificate of WHO laboratory Center-Free Universitat Berlin(2005).He is currently work as senior lecturer in USM, Kelantan, Malaysia.Most of his works were published in local and international journals in the field of biotechnology,pharmacology and toxicology.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
384849678X
ISBN 13 
9783848496785
Reliure
Broché
Nombre de pages
224
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne