Drug Delivery Strategy: Co-precipitation Method Of Solid Dispersion: A Formulation Strategy for Poorly Soluble Drugs - Couverture souple

Kadir, Mohammad Fahim; Bin Sayeed, Muhammad Shahdaat

 
9783848498642: Drug Delivery Strategy: Co-precipitation Method Of Solid Dispersion: A Formulation Strategy for Poorly Soluble Drugs
Couverture souple
ISBN 10 : 3848498642 ISBN 13 : 9783848498642
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Solid dispersion technology has proved to be a powerful technique in the field of drug delivery of poorly water soluble drugs by enhancing the dissolution rate and bioavailability of that drug. Here we used four drugs namely Spironolactone, Etoricoxib, Ibuprofen and Carvedilol. Solid dispersions were prepared by solvent co-precipitation method, where acetone was used as solvent and pet-ether was used as anti solvent. Different water soluble polymer (HPMC 6cps, Kollicoat IR, Kollidon VA 64 and HPC), and as an excipient poloxamer were used to prepare solid dispersion. Paddle type dissolution apparatus was used to study in-vitro dissolution rate, where paddle speed was 75 rpm. at 37°C. The dissolution samples were then analyzed spectrophotometrically by UV-VIS spectrophotometer. At first we tried to identify the effect of poloxamer 407, then with poloxamer others polymer were applied to find out their effect on drugs. Through the entire study, we searched for the suitable polymer and excipient with their proportion in a formulation which would show the best beneficial effect on drugs’ dissolution rate.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Solid dispersion technology has proved to be a powerful technique in the field of drug delivery of poorly water soluble drugs by enhancing the dissolution rate and bioavailability of that drug. Here we used four drugs namely Spironolactone, Etoricoxib, Ibuprofen and Carvedilol. Solid dispersions were prepared by solvent co-precipitation method, where acetone was used as solvent and pet-ether was used as anti solvent. Different water soluble polymer (HPMC 6cps, Kollicoat IR, Kollidon VA 64 and HPC), and as an excipient poloxamer were used to prepare solid dispersion. Paddle type dissolution apparatus was used to study in-vitro dissolution rate, where paddle speed was 75 rpm. at 37°C. The dissolution samples were then analyzed spectrophotometrically by UV-VIS spectrophotometer. At first we tried to identify the effect of poloxamer 407, then with poloxamer others polymer were applied to find out their effect on drugs. Through the entire study, we searched for the suitable polymer and excipient with their proportion in a formulation which would show the best beneficial effect on drugs’ dissolution rate.

Biographie de l'auteur

Mohammad Fahim Kadir obtained Master of Pharmacy Degree in Pharmaceutical Technology from the University of Dhaka, Bangladesh. Muhammad Shahdaat Bin Sayeed Bin Sayeed obtained Bachelor Pharmacy (Hons.)from the Faculty of Pharmacy in the University of Dhaka. They teach at the Department of Pharmacy in the University of Asia Pacific, Bangladesh.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848498642
ISBN 13 
9783848498642
Reliure
Broché
Nombre de pages
192
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne