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Innovatioon 5-Fluoruracil SR Tablets for Colon Cancer Treatment: To optimize the challenges across formulation strategies and targeting colon - Couverture souple

Mehta, Tarak Jayraj; Patel, DR.Natvarlal M.; Patel, DR.Mukesh R.

 
9783848499205: Innovatioon 5-Fluoruracil SR Tablets for Colon Cancer Treatment: To optimize the challenges across formulation strategies and targeting colon
Couverture souple
ISBN 10 : 3848499207 ISBN 13 : 9783848499205
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The use of polymeric matrix devices to control the release of variety of therapeutic agents has become increasingly important in development of the modified release dosage forms. The device may be a swellable, hydrophilic monolithic systems, an erosion controlled monolithic system or a non erodible system. The initial burst release of 5-Fluoruracil from such matrix tablet surface can be controlled by compression coating technology. Appropriate combination of hydrophilic polymer in upper and lower layer of tablet can govern the release of 5-fluoruracil as well as lag time to deliver it in effective concentration to the colon with reduced toxicity. The lag time can be controlled by appropriate combination of polymer and excipients in coating layer. The release mechanism of 5-fluoruracil from the compression coated tablets was controlled by the rate of water uptake into the core tablet, which in turn was dependent upon the channeling agent used, the type and concentration of polymer. The hydration and swelling of these polymers results in the formation of gel which control the release of 5-fluoruracil from tablet.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The use of polymeric matrix devices to control the release of variety of therapeutic agents has become increasingly important in development of the modified release dosage forms. The device may be a swellable, hydrophilic monolithic systems, an erosion controlled monolithic system or a non erodible system. The initial burst release of 5-Fluoruracil from such matrix tablet surface can be controlled by compression coating technology. Appropriate combination of hydrophilic polymer in upper and lower layer of tablet can govern the release of 5-fluoruracil as well as lag time to deliver it in effective concentration to the colon with reduced toxicity. The lag time can be controlled by appropriate combination of polymer and excipients in coating layer. The release mechanism of 5-fluoruracil from the compression coated tablets was controlled by the rate of water uptake into the core tablet, which in turn was dependent upon the channeling agent used, the type and concentration of polymer. The hydration and swelling of these polymers results in the formation of gel which control the release of 5-fluoruracil from tablet.

Biographie de l'auteur

Mr.Tarak Jayraj Mehta did his B.Pharmacy From Rajiv Gandhi University,M.Pharmacy From S.R.M.University,and Persuing Ph.D. From JJT University,Jhunjhunu,he has started his carrier from B.M.C.P.E.R.,Modasa as a Lecturer,he has Published a number of Research Papers in National and International journals.he has successfully passed WIPO Exam,Switzerland

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3848499207
ISBN 13 
9783848499205
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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