Protein Adsorption to Vial Surfaces - Quantification, Structural and Mechanistic Studies - Couverture souple

Mathes, Johannes

9783869554815: Protein Adsorption to Vial Surfaces - Quantification, Structural and Mechanistic Studies

Couverture souple

ISBN 10 : 3869554819 ISBN 13 : 9783869554815

Editeur : Cuvillier Verlag, 2010

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�diteur: Cuvillier Verlag
Date d'�dition: 2010
Langue: anglais
ISBN 10: 3869554819
ISBN 13: 9783869554815
Reliure: Broch�
Nombre de pages: 256
Coordonn�es du fabricant: non disponible
Personne responsable: non disponible

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Protein Adsorption to Vial Surfaces - Quantification, Structural and Mechanistic Studies

Johannes Mathes

Edit� par Cuvillier Sep 2010, 2010

ISBN 10 : 3869554819 ISBN 13 : 9783869554815

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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The adsorption of therapeutic proteins to different surfaces in the course of fill and finish, storage, or administration is critical and has shown to cause severe problems which should not be underestimated. Among them is the loss of content but also, potentially, protein structural changes, accompanied by the risk of therapy failure or immunological reactions. In this context, special attention has to be paid to primary packaging containers, to which the protein has an enduring surface contact. Against this background, the adsorption of a modern therapeutic protein, i.e. an IgG1 antibody, to vials was investigated within the scope of this thesis. The first priority had borosilicate glass, followed by siliconized borosilicate glass and polyolefin plastic. The use of model surfaces was almost completely avoided. The studies comprise the quantification of surface-bound protein subject to variable formulation compositions and surface qualities as well as a detailed characterization of the adsorbed protein layer including protein structural alterations caused by the adsorption process. In the presented investigations, the main focus was on the equilibrium state of adsorption at conditions mainly within the scope of pharmaceutical relevance, but also beyond, if necessary, for the acquisition of fundamental knowledge on the adsorption mechanism. 256 pp. Englisch. N� de r�f. du vendeur 9783869554815

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Protein Adsorption to Vial Surfaces - Quantification, Structural and Mechanistic Studies

Mathes, Johannes

Edit� par Jentzsch-Cuvillier, Annette, 2010

ISBN 10 : 3869554819 ISBN 13 : 9783869554815

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. KlappentextrnrnThe adsorption of therapeutic proteins to different surfaces in the course of fill and finish, storage, or administration is critical and has shown to cause severe problems which should not be underestimated. Among them is the los. N� de r�f. du vendeur 140500263

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Protein Adsorption to Vial Surfaces - Quantification, Structural and Mechanistic Studies

Johannes Mathes

Edit� par Cuvillier, Cuvillier Sep 2010, 2010

ISBN 10 : 3869554819 ISBN 13 : 9783869554815

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Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The adsorption of therapeutic proteins to different surfaces in the course of fill and finish, storage, or administration is critical and has shown to cause severe problems which should not be underestimated. Among them is the loss of content but also, potentially, protein structural changes, accompanied by the risk of therapy failure or immunological reactions. In this context, special attention has to be paid to primary packaging containers, to which the protein has an enduring surface contact.Against this background, the adsorption of a modern therapeutic protein, i.e. an IgG1 antibody, to vials was investigated within the scope of this thesis. The first priority had borosilicate glass, followed by siliconized borosilicate glass and polyolefin plastic. The use of model surfaces was almost completely avoided. The studies comprise the quantification of surface-bound protein subject to variable formulation compositions and surface qualities as well as a detailed characterization of the adsorbed protein layer including protein structural alterations caused by the adsorption process. In the presented investigations, the main focus was on the equilibrium state of adsorption at conditions mainly within the scope of pharmaceutical relevance, but also beyond, if necessary, for the acquisition of fundamental knowledge on the adsorption mechanism.Cuvillier Verlag, Nonnenstieg 8, 37075 G�ttingen 256 pp. Englisch. N� de r�f. du vendeur 9783869554815

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Protein Adsorption to Vial Surfaces - Quantification, Structural and Mechanistic Studies

Johannes Mathes

Edit� par Cuvillier

ISBN 10 : 3869554819 ISBN 13 : 9783869554815

Neuf Taschenbuch

impression � la demande

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The adsorption of therapeutic proteins to different surfaces in the course of fill and finish, storage, or administration is critical and has shown to cause severe problems which should not be underestimated. Among them is the loss of content but also, potentially, protein structural changes, accompanied by the risk of therapy failure or immunological reactions. In this context, special attention has to be paid to primary packaging containers, to which the protein has an enduring surface contact. Against this background, the adsorption of a modern therapeutic protein, i.e. an IgG1 antibody, to vials was investigated within the scope of this thesis. The first priority had borosilicate glass, followed by siliconized borosilicate glass and polyolefin plastic. The use of model surfaces was almost completely avoided. The studies comprise the quantification of surface-bound protein subject to variable formulation compositions and surface qualities as well as a detailed characterization of the adsorbed protein layer including protein structural alterations caused by the adsorption process. In the presented investigations, the main focus was on the equilibrium state of adsorption at conditions mainly within the scope of pharmaceutical relevance, but also beyond, if necessary, for the acquisition of fundamental knowledge on the adsorption mechanism. N� de r�f. du vendeur 9783869554815

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