Computational Approaches for Identifying Drugs Against Alzheimer's Disease - Couverture souple

Mahendran, Dr. Radha

Couverture souple

ISBN 10 : 3960671385 ISBN 13 : 9783960671381

Editeur : Anchor Academic Publishing, 2017

Synopsis

Alzheimer's disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer's disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library. The concept of QSAR has typically been used for drug discovery and development and has gained wide applicability for correlating molecular information with not only biological activities but also with other physicochemical properties, which has therefore been termed quantitative structure-property relationship (QSPR). In this study, 3D QSAR and pharmacophore mapping studies were carried out using Accelrys Discovery Studio 2.1. The best nine drugs were selected from the 16 ligands and pharmacophore features were generated.

Détails de l'édition

• Éditeur: Anchor Academic Publishing
• Date d'édition: 2017
• Langue: anglais
• ISBN 10: 3960671385
• ISBN 13: 9783960671381
• Reliure: Broché
• Nombre de pages: 72
• Coordonnées du fabricant: non disponible
• Personne responsable: KreGa Onlinehandel GmbH; 4950000000000; info@krega-onlinehandel.de; ; Birkenweg 31; Brakel; 33034; Allemagne