How the Immune System Recognizes Self and Nonself: Immunoreceptors and Their Signaling - Couverture rigide

Couverture rigide

ISBN 10 : 4431738835 ISBN 13 : 9784431738831

Editeur : Springer Verlag, Japan, 2007

Synopsis

How do you discriminate yourself from other people? This question must sound odd to you since you easily recognize others at a glance and, without any effort, would not mistake them for yourself. However, it is not always easy for some people to discriminate themselves from others. For example, patients with schi- phrenia often talk with "others" living inside themselves. Thus it is likely that n- mally your brain actively recognizes and remembers the information belonging to yourself and discriminates it from the information provided by others, although you are not conscious of it. This brain function must have been particularly important for most animals to protect their lives from enemies and for species to survive through evolution. Similarly, higher organisms have also acquired their immune system through evolution that discriminates nonself pathogens and self-body to protect their lives from pathogens such as bacteria or viruses. The brain system may distinguish integrated images of self and nonself created from many inputs, such as vision, sound, smell, and others. The immune system recognizes and distinguishes a variety of structural features of self and nonself components. The latter actually include almost everything but self: for example, bacteria, viruses, toxins, pollens, chemicals, transplanted organs, and even tumor cells derived from self-tissue. To this end the immune system recruits different kinds of immune cells, such as B and T lymphocytes, natural killer (NK) cells, dendritic cells, and macrophages.

A propos du livre

Présentation de l'éditeur

The immune system is a highly evolved security system that protects the body from infection by pathogens such as viruses and bacteria. The immune system also recognizes and rejects a transplanted organ from even the same species. Indeed, the immune system potentially recognizes and eliminates everything that invades the body (nonself). However, it does not normally eliminate self cells or tissues except tumor cells developed from self tissue. Occasionally the immune system breaks down and attacks the body components of the self, manifesting as autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, myasthenia gravis, and insulin-resistant diabetes. This book contains extensive updated reviews describing what kinds of receptors various immune cells use, how they recognize the self and the nonself components (and "neoself" such as tumors), and how finally the immune system distinguishes the self and nonself - a far more complicated process than a computer security system detecting infected documents. Perfect understanding of this system should make it possible in the future to regulate immunity to transplants, to cure autoimmune disease and allergy, and to facilitate tumor immunity.

Détails de l'édition

• Éditeur: Springer Verlag, Japan
• Date d'édition: 2007
• Langue: anglais
• ISBN 10: 4431738835
• ISBN 13: 9784431738831
• Reliure: Relié
• Nombre de pages: 269
• Éditeur: Kitamura Daisuke
• Coordonnées du fabricant: non disponible
• Personne responsable: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Allemagne