Articles liés à Effect of Synthetic Oxytocin on Neuroendocrine and...

Effect of Synthetic Oxytocin on Neuroendocrine and Reproductive System: Impact of synthetic oxytocin on Neuroendocrine, Endocrine and Reproductive system of female albino mice - Couverture souple

Jain, Neha

 
9786134976756: Effect of Synthetic Oxytocin on Neuroendocrine and Reproductive System: Impact of synthetic oxytocin on Neuroendocrine, Endocrine and Reproductive system of female albino mice
Couverture souple
ISBN 10 : 613497675X ISBN 13 : 9786134976756
Editeur : LAP LAMBERT Academic Publishing, 2018

Synopsis

In mammals nonapeptide oxytocin (OT) exerts many different biological functions through G-protein-coupled transmembrane receptors-OTR and vasopressin receptors viz., V1 (V1a and V1b) and V2 type. OT is effective after administration by any parenteral route such as i.p., s.c., i.m., i.v., intranasal and orally. This thesis explored about the toxicity bioassay of synthetic OT on female mice. In connection to this, 36 female mice were randomly allocated into 2 groups as control (n=18) and treated (n=18). The treated and control groups were received intraperitonial (i.p.) dose of synthetic OT (50mIU/g body weight) and physiological saline respectively for different duration i.e. 30, 60 and 90 days from postnatal day 10±5. The body and relative organ weight; estrus cycle; hematological; serum biochemical and enzymological analysis; serum hormonal assay; biogenic amine estimations in total brain; and histopathological study were performed. Statistical analyses were performed by one way ANOVA and SEM. This research was done according to the protocol of Institutional Animals Ethics Committee (IAEC), Barkatullah University, Bhopal, India with Reg. No. 1885/GO/Re/S/16/CPCSEA/IAEC/BU/07.

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Présentation de l'éditeur

In mammals nonapeptide oxytocin (OT) exerts many different biological functions through G-protein-coupled transmembrane receptors-OTR and vasopressin receptors viz., V1 (V1a and V1b) and V2 type. OT is effective after administration by any parenteral route such as i.p., s.c., i.m., i.v., intranasal and orally. This thesis explored about the toxicity bioassay of synthetic OT on female mice. In connection to this, 36 female mice were randomly allocated into 2 groups as control (n=18) and treated (n=18). The treated and control groups were received intraperitonial (i.p.) dose of synthetic OT (50mIU/g body weight) and physiological saline respectively for different duration i.e. 30, 60 and 90 days from postnatal day 10±5. The body and relative organ weight; estrus cycle; hematological; serum biochemical and enzymological analysis; serum hormonal assay; biogenic amine estimations in total brain; and histopathological study were performed. Statistical analyses were performed by one way ANOVA and SEM. This research was done according to the protocol of Institutional Animals Ethics Committee (IAEC), Barkatullah University, Bhopal, India with Reg. No. 1885/GO/Re/S/16/CPCSEA/IAEC/BU/07.

Biographie de l'auteur

Dr. Neha Jain[PhD, MPhil, MSc (Biotechnology & Chemistry), BEd, GATE, A Website Designer]Laboratory of Endocrinology, Department of Biosciences,Barkatullah University, Bhopal-462026, Madhya Pradesh, INDIA

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2018
Langue
anglais
ISBN 10 
613497675X
ISBN 13 
9786134976756
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
Personne responsable
non disponible