Formulation and optimization of floating matrix tablets of salbutamol - Couverture souple

Name: Formulation and optimization of floating matrix tablets of salbutamol
Author: Dlie, Zewdu Yilma; Belete, Anteneh; Gebre-Mariam, Tsige
ISBN: 9786134997843

Dlie, Zewdu Yilma ; Belete, Anteneh ; Gebre-Mariam, Tsige

9786134997843: Formulation and optimization of floating matrix tablets of salbutamol

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ISBN 10 : 6134997846 ISBN 13 : 9786134997843

Editeur : LAP LAMBERT Academic Publishing, 2019

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Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its dosing frequency. Accordingly, floating tablets were prepared by wet granulation technique and drug release analysis was performed by HPLC. The effects of polymer level, polymer type (XG or HPMC), polymer ratio (XG/HPMC; 1:1, 1:3, 3:1) and NaHCO3 level on floating lag time, floating duration, cumulative release within 1 hr, and release rate were investigated. From preliminary studies, the polymer with 1:3 (XG:HPMC) ratio and NaHCO3 were selected as significant factors and cumulative release at 1 hr and release rate were chosen as significant responses, respectively. Hence, the effect of these factors was further studied and optimized by central composite design. The most desirable representative optimal point was obtained at 24.79% of XG/HPMC and 5% of NaHCO3 having a release rate of 28.4.

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2019
Langue: anglais
ISBN 10: 6134997846
ISBN 13: 9786134997843
Reliure: Broch�
Nombre de pages: 52
Coordonn�es du fabricant: non disponible
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Formulation and optimization of floating matrix tablets of salbutamol

Zewdu Yilma Dlie

Edit� par LAP LAMBERT Academic Publishing Jan 2019, 2019

ISBN 10 : 6134997846 ISBN 13 : 9786134997843

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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its dosing frequency. Accordingly, floating tablets were prepared by wet granulation technique and drug release analysis was performed by HPLC. The effects of polymer level, polymer type (XG or HPMC), polymer ratio (XG/HPMC; 1:1, 1:3, 3:1) and NaHCO3 level on floating lag time, floating duration, cumulative release within 1 hr, and release rate were investigated. From preliminary studies, the polymer with 1:3 (XG:HPMC) ratio and NaHCO3 were selected as significant factors and cumulative release at 1 hr and release rate were chosen as significant responses, respectively. Hence, the effect of these factors was further studied and optimized by central composite design. The most desirable representative optimal point was obtained at 24.79% of XG/HPMC and 5% of NaHCO3 having a release rate of 28.4. 52 pp. Englisch. N� de r�f. du vendeur 9786134997843

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Formulation and optimization of floating matrix tablets of salbutamol

Tsige Gebre-Mariam

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6134997846 ISBN 13 : 9786134997843

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its dosing frequency. Accordingly, floating tablets were prepared by wet granulation technique and drug release analysis was performed by HPLC. The effects of polymer level, polymer type (XG or HPMC), polymer ratio (XG/HPMC; 1:1, 1:3, 3:1) and NaHCO3 level on floating lag time, floating duration, cumulative release within 1 hr, and release rate were investigated. From preliminary studies, the polymer with 1:3 (XG:HPMC) ratio and NaHCO3 were selected as significant factors and cumulative release at 1 hr and release rate were chosen as significant responses, respectively. Hence, the effect of these factors was further studied and optimized by central composite design. The most desirable representative optimal point was obtained at 24.79% of XG/HPMC and 5% of NaHCO3 having a release rate of 28.4. N� de r�f. du vendeur 9786134997843

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Formulation and optimization of floating matrix tablets of salbutamol

Zewdu Yilma Dlie|Anteneh Belete|Tsige Gebre-Mariam

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6134997846 ISBN 13 : 9786134997843

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Kartoniert / Broschiert. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Dlie Zewdu YilmaZewdu Yilma Dlie is an instructor and researcher in the Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. He completed his B.Pharm degree at Mekelle University. N� de r�f. du vendeur 274028403

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Formulation and optimization of floating matrix tablets of salbutamol

Zewdu Yilma Dlie

Edit� par LAP LAMBERT Academic Publishing Jan 2019, 2019

ISBN 10 : 6134997846 ISBN 13 : 9786134997843

Neuf Taschenbuch

impression � la demande

Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

�valuation du vendeur 5 sur 5 �toiles

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Oral salbutamol sulphate has site-specific absorption in the stomach and upper part of the small intestine. Its bioavailability is about 40% due to several factors including narrow absorption window and extensive intestinal metabolism. The aim of this study was to formulate and optimize sustained release floating tablets of salbutamol sulphate in order to improve its bioavailability and reduce its dosing frequency. Accordingly, floating tablets were prepared by wet granulation technique and drug release analysis was performed by HPLC. The effects of polymer level, polymer type (XG or HPMC), polymer ratio (XG/HPMC; 1:1, 1:3, 3:1) and NaHCO3 level on floating lag time, floating duration, cumulative release within 1 hr, and release rate were investigated. From preliminary studies, the polymer with 1:3 (XG:HPMC) ratio and NaHCO3 were selected as significant factors and cumulative release at 1 hr and release rate were chosen as significant responses, respectively. Hence, the effect of these factors was further studied and optimized by central composite design. The most desirable representative optimal point was obtained at 24.79% of XG/HPMC and 5% of NaHCO3 having a release rate of 28.4.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 52 pp. Englisch. N� de r�f. du vendeur 9786134997843

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