The Enzymes in Synthesis of Chiral Bioactive Compounds - Couverture souple

Mahmoud Morsy Mohamed, Nesrin; Hamed Imam Ismael, Eman; Abdallah A. Yosef, Hisham

Couverture souple

ISBN 10 : 6138912845 ISBN 13 : 9786138912842

Editeur : Scholars' Press, 2019

Synopsis

The administration of chiral compounds in an enantiomerically pure form, instead of racemic mixtures, become an important issue especially in the pharmaceutical and agrochemical industries due to the well established correlation between the biological activity and stereochemistry. Pure enantiomers could be formed by the asymmetric synthesis and /or the resolution of racemates. This could be achieved by the use of enzymes as chiral catalysts. The advantages of enzymes are their high stereo- (chiral), regio- (positional) and chemo- (functional group specific) selectivity. This selectivity offers several benefits like high catalytic efficiency, preservation of asymmetric centres, single step transformations, easier separation, mild operating conditions and fewer environmental problems. The organic reactions that are catalyzed by enzymes to give chiral bioactive organic compounds include, for example, reduction (e.g. by dehydrogenases, ketoreductases), oxidation (e.g. by monooxygenases, dioxygenases), hydrolytic (e.g. by lipases, esterases) reactions.

Détails de l'édition

• Éditeur: Scholars' Press
• Date d'édition: 2019
• Langue: anglais
• ISBN 10: 6138912845
• ISBN 13: 9786138912842
• Reliure: Broché
• Nombre de pages: 92
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible