The cotransporter NaPi-IIa: enzyme-dependent activity regulation: Cellular mechanisms and health effects - Couverture souple

Dërmaku-Sopjani, Miribane; Sopjani, Mentor

Couverture souple

ISBN 10 : 6139457777 ISBN 13 : 9786139457779

Editeur : LAP LAMBERT Academic Publishing, 2019

Synopsis

The sodium-coupled phosphate transporter NaPi-IIa is the main cellular carrier accomplishing kidney phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the basolateral cell membrane through the Na+/K+ ATPase. Energy starvation is sensed by the AMPK, a serine/threonine kinase stimulating several cellular mechanisms increasing energy production and limiting energy consumption. AMPK provides a critical link between energy metabolism and cellular transport. The aging suppressor Klotho, a transmembrane protein, is a protease and hormone has been shown to exert a profound effect on phosphate metabolism, aging, and lifespan. Additionally, the enzymes SGK1, mTOR, Akt/PKB and Nedd4-2 are of critical importance for a wide variety of functions including bone mineralization and energy metabolism. The present book explores the mechanisms of phosphate homeostasis and the role of AMPK, Klotho, SGK1, mTOR, Akt/PKB and Nedd4-2 in the regulation of NaPi-IIa activity.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2019
• Langue: anglais
• ISBN 10: 6139457777
• ISBN 13: 9786139457779
• Reliure: Broché
• Nombre de pages: 120
• Coordonnées du fabricant: non disponible
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