Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents - Couverture souple

Jani, Dr. Rupalben Kaushalkumar

9786139458738: Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

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ISBN 10 : 6139458730 ISBN 13 : 9786139458738

Editeur : LAP LAMBERT Academic Publishing, 2019

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The aim of the present investigation was to develop and characterize transdermal matrix patch of Lercanidipine hydrochloride and Diltiazem hydrochloride for controlled drug delivery by the solvent evaporation method. To achieve controlled drug release, polymers such as psyllium and HPMC K15M were optimized. Moreover, the skin permeation effect of essential oils such as linseed oil, jojoba oil and pumpkin seed oil were investigated on wistar rat skin. A 32 full factorial design applied to optimize two formulation variables: concentration of essential oil as a permeation enhancer and polymer fixed-weight ratio. To study drug-excipients incompatibility Fourier transforms infrared spectroscopy (FTIR) had employed, which showed the absence of chemical interaction. All formulations evaluated for physicochemical parameters, ex-vivo permeation study, in-vivo skin-irritation study on wistar rats and stability study. Developed matrix patch showed optimum physicochemical properties with the absence of skin irritation. Ex-vivo permeation study revealed that both formulation variables show an effect on drug release from matrix patches.

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2019
Langue: anglais
ISBN 10: 6139458730
ISBN 13: 9786139458738
Reliure: Broch�
Nombre de pages: 184
Coordonn�es du fabricant: non disponible
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Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

Rupalben Kaushalkumar Jani

Edit� par LAP LAMBERT Academic Publishing Mrz 2019, 2019

ISBN 10 : 6139458730 ISBN 13 : 9786139458738

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The aim of the present investigation was to develop and characterize transdermal matrix patch of Lercanidipine hydrochloride and Diltiazem hydrochloride for controlled drug delivery by the solvent evaporation method. To achieve controlled drug release, polymers such as psyllium and HPMC K15M were optimized. Moreover, the skin permeation effect of essential oils such as linseed oil, jojoba oil and pumpkin seed oil were investigated on wistar rat skin. A 32 full factorial design applied to optimize two formulation variables: concentration of essential oil as a permeation enhancer and polymer fixed-weight ratio. To study drug-excipients incompatibility Fourier transforms infrared spectroscopy (FTIR) had employed, which showed the absence of chemical interaction. All formulations evaluated for physicochemical parameters, ex-vivo permeation study, in-vivo skin-irritation study on wistar rats and stability study. Developed matrix patch showed optimum physicochemical properties with the absence of skin irritation. Ex-vivo permeation study revealed that both formulation variables show an effect on drug release from matrix patches. 184 pp. Englisch. N� de r�f. du vendeur 9786139458738

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Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

Dr. Rupalben Kaushalkumar Jani

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6139458730 ISBN 13 : 9786139458738

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Jani Dr. Rupalben KaushalkumarDr Rupal Jani-Associate Professor in Parul Institute of Pharmacy and Research, Pharmaceutics Department, along with academic dutiesshe is also chief coordinator of All India Survey on Higher Education . N� de r�f. du vendeur 385859458

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Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

Rupalben Kaushalkumar Jani

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6139458730 ISBN 13 : 9786139458738

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Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

Rupalben Kaushalkumar Jani

Edit� par LAP LAMBERT Academic Publishing M�r 2019, 2019

ISBN 10 : 6139458730 ISBN 13 : 9786139458738

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The aim of the present investigation was to develop and characterize transdermal matrix patch of Lercanidipine hydrochloride and Diltiazem hydrochloride for controlled drug delivery by the solvent evaporation method. To achieve controlled drug release, polymers such as psyllium and HPMC K15M were optimized. Moreover, the skin permeation effect of essential oils such as linseed oil, jojoba oil and pumpkin seed oil were investigated on wistar rat skin. A 32 full factorial design applied to optimize two formulation variables: concentration of essential oil as a permeation enhancer and polymer fixed-weight ratio. To study drug-excipients incompatibility Fourier transforms infrared spectroscopy (FTIR) had employed, which showed the absence of chemical interaction. All formulations evaluated for physicochemical parameters, ex-vivo permeation study, in-vivo skin-irritation study on wistar rats and stability study. Developed matrix patch showed optimum physicochemical properties with the absence of skin irritation. Ex-vivo permeation study revealed that both formulation variables show an effect on drug release from matrix patches.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 184 pp. Englisch. N� de r�f. du vendeur 9786139458738

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Fabrication And Evaluation Of Transdermal Systems Containing Antihypertensive Agents

Rupalben Kaushalkumar Jani

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6139458730 ISBN 13 : 9786139458738

Neuf Taschenbuch

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Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The aim of the present investigation was to develop and characterize transdermal matrix patch of Lercanidipine hydrochloride and Diltiazem hydrochloride for controlled drug delivery by the solvent evaporation method. To achieve controlled drug release, polymers such as psyllium and HPMC K15M were optimized. Moreover, the skin permeation effect of essential oils such as linseed oil, jojoba oil and pumpkin seed oil were investigated on wistar rat skin. A 32 full factorial design applied to optimize two formulation variables: concentration of essential oil as a permeation enhancer and polymer fixed-weight ratio. To study drug-excipients incompatibility Fourier transforms infrared spectroscopy (FTIR) had employed, which showed the absence of chemical interaction. All formulations evaluated for physicochemical parameters, ex-vivo permeation study, in-vivo skin-irritation study on wistar rats and stability study. Developed matrix patch showed optimum physicochemical properties with the absence of skin irritation. Ex-vivo permeation study revealed that both formulation variables show an effect on drug release from matrix patches. N� de r�f. du vendeur 9786139458738

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