The role of complement system in haematosis and thrombosis - Couverture souple

Abdwrahman Karim, Shokhan

 
9786139819348: The role of complement system in haematosis and thrombosis
Couverture souple
ISBN 10 : 6139819342 ISBN 13 : 9786139819348
Editeur : LAP LAMBERT Academic Publishing, 2018

Synopsis

Complement is a system of plasma proteins that has important roles in the innate and adaptive immune responses. It is closely related to the coagulation system and the two are interconnected. There are three different pathways of complement activation, the classical, lectin and alternative pathways. The lectin pathway is activated when a multi-molecular activation complex binds to carbohydrate structures on microorganisms, or aberrant glycocalyx patterns on apoptotic, necrotic, or malignant cells. Lectin pathway activation complexes comprise a carbohydrate recognition molecule (mannan-binding lectin [MBL], collectin 11, or a ficolin) and MBL-associated serine proteases (MASP-1, -2 and -3). It has been reported that MBL-MASP complexes have a role in clot formation; MASP-1 activating fibrinogen and factor XIII, and MASP-2 activating prothrombin. Clots are generated when classified plasma is incubated with Ficolin-MASP and MBL-MASP complexes. The aim of this project was to study role of the MASPs in fibrin clot formation and to identify where the lectin pathway intercepts the coagulation system. A turbidimetric clotting assay was developed.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Complement is a system of plasma proteins that has important roles in the innate and adaptive immune responses. It is closely related to the coagulation system and the two are interconnected. There are three different pathways of complement activation, the classical, lectin and alternative pathways. The lectin pathway is activated when a multi-molecular activation complex binds to carbohydrate structures on microorganisms, or aberrant glycocalyx patterns on apoptotic, necrotic, or malignant cells. Lectin pathway activation complexes comprise a carbohydrate recognition molecule (mannan-binding lectin [MBL], collectin 11, or a ficolin) and MBL-associated serine proteases (MASP-1, -2 and -3). It has been reported that MBL-MASP complexes have a role in clot formation; MASP-1 activating fibrinogen and factor XIII, and MASP-2 activating prothrombin. Clots are generated when classified plasma is incubated with Ficolin-MASP and MBL-MASP complexes. The aim of this project was to study role of the MASPs in fibrin clot formation and to identify where the lectin pathway intercepts the coagulation system. A turbidimetric clotting assay was developed.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2018
Langue
anglais
ISBN 10 
6139819342
ISBN 13 
9786139819348
Reliure
Broché
Nombre de pages
68
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne