New Biomarkers in Evaluating Interactions of Two Cytotoxic Agents - Couverture souple

El-Habit, Ola ; Mumtaz Daowd, Farah ; Esmat Abdel-Moniem, Ahmed

9786139822515: New Biomarkers in Evaluating Interactions of Two Cytotoxic Agents

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ISBN 10 : 6139822513 ISBN 13 : 9786139822515

Editeur : LAP LAMBERT Academic Publishing, 2018

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We tested the cytotoxicity; gene expression of miR146a and let7a; oxidative stress and antioxidant enzymes activity and the histopathological changes in liver tissues of rat. Two dose of NaAsO2 (5mg/kg) and CdCl2 (1 mg/kg) were administered by oral gavage and intraperitoneally injection, respectively, for 14 and 28 consecutive days. We evaluated the possible interaction between cadmium and arsenate. Very few reports have addressed the possible interaction of chronic concontaminant exposures to mixtures of these metals in both occupational and environmental settings. Metal-metal interaction may lead to severe adverse effects by enhancing the effects of both metals through some additive or synergistic actions. The study concluded that there are a close relationship of high epigenetic changes as deregulation of both (miR146a) and (miRlet7a) due to the toxic effect of sodium arsenite and cadmium chloride alone or in combination and a major changes in hepatic tissues that may lead to cell transformations from normal to becoming cancerous cells.

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2018
Langue: anglais
ISBN 10: 6139822513
ISBN 13: 9786139822515
Reliure: Broch�
Nombre de pages: 168
Coordonn�es du fabricant: non disponible
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New Biomarkers in Evaluating Interactions of Two Cytotoxic Agents

Ola El-Habit

Edit� par LAP LAMBERT Academic Publishing Apr 2018, 2018

ISBN 10 : 6139822513 ISBN 13 : 9786139822515

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We tested the cytotoxicity; gene expression of miR146a and let7a; oxidative stress and antioxidant enzymes activity and the histopathological changes in liver tissues of rat. Two dose of NaAsO2 (5mg/kg) and CdCl2 (1 mg/kg) were administered by oral gavage and intraperitoneally injection, respectively, for 14 and 28 consecutive days. We evaluated the possible interaction between cadmium and arsenate. Very few reports have addressed the possible interaction of chronic concontaminant exposures to mixtures of these metals in both occupational and environmental settings. Metal-metal interaction may lead to severe adverse effects by enhancing the effects of both metals through some additive or synergistic actions. The study concluded that there are a close relationship of high epigenetic changes as deregulation of both (miR146a) and (miRlet7a) due to the toxic effect of sodium arsenite and cadmium chloride alone or in combination and a major changes in hepatic tissues that may lead to cell transformations from normal to becoming cancerous cells. 168 pp. Englisch. N� de r�f. du vendeur 9786139822515

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New Biomarkers in Evaluating Interactions of Two Cytotoxic Agents

Ola El-Habit|Farah Mumtaz Daowd|Ahmed Esmat Abdel-Moniem

Edit� par LAP LAMBERT Academic Publishing, 2018

ISBN 10 : 6139822513 ISBN 13 : 9786139822515

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: El-Habit OlaOla El-Habit Prof. of Genetics, Faculty of Science, Zoology and Entomology Department, Helwan University. Ex. Head of Zoology and Entomology Department, Helwan University. Prof. of Genetics, Zoology Department, King Saud . N� de r�f. du vendeur 385872643

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New Biomarkers in Evaluating Interactions of Two Cytotoxic Agents

Ola El-Habit

Edit� par LAP LAMBERT Academic Publishing, 2018

ISBN 10 : 6139822513 ISBN 13 : 9786139822515

Neuf Taschenbuch

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Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - We tested the cytotoxicity; gene expression of miR146a and let7a; oxidative stress and antioxidant enzymes activity and the histopathological changes in liver tissues of rat. Two dose of NaAsO2 (5mg/kg) and CdCl2 (1 mg/kg) were administered by oral gavage and intraperitoneally injection, respectively, for 14 and 28 consecutive days. We evaluated the possible interaction between cadmium and arsenate. Very few reports have addressed the possible interaction of chronic concontaminant exposures to mixtures of these metals in both occupational and environmental settings. Metal-metal interaction may lead to severe adverse effects by enhancing the effects of both metals through some additive or synergistic actions. The study concluded that there are a close relationship of high epigenetic changes as deregulation of both (miR146a) and (miRlet7a) due to the toxic effect of sodium arsenite and cadmium chloride alone or in combination and a major changes in hepatic tissues that may lead to cell transformations from normal to becoming cancerous cells. N� de r�f. du vendeur 9786139822515

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New Biomarkers in Evaluating Interactions of Two Cytotoxic Agents

Ola El-Habit

Edit� par LAP LAMBERT Academic Publishing Apr 2018, 2018

ISBN 10 : 6139822513 ISBN 13 : 9786139822515

Neuf Taschenbuch

impression � la demande

Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -We tested the cytotoxicity; gene expression of miR146a and let7a; oxidative stress and antioxidant enzymes activity and the histopathological changes in liver tissues of rat. Two dose of NaAsO2 (5mg/kg) and CdCl2 (1 mg/kg) were administered by oral gavage and intraperitoneally injection, respectively, for 14 and 28 consecutive days. We evaluated the possible interaction between cadmium and arsenate. Very few reports have addressed the possible interaction of chronic concontaminant exposures to mixtures of these metals in both occupational and environmental settings. Metal-metal interaction may lead to severe adverse effects by enhancing the effects of both metals through some additive or synergistic actions. The study concluded that there are a close relationship of high epigenetic changes as deregulation of both (miR146a) and (miRlet7a) due to the toxic effect of sodium arsenite and cadmium chloride alone or in combination and a major changes in hepatic tissues that may lead to cell transformations from normal to becoming cancerous cells.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 168 pp. Englisch. N� de r�f. du vendeur 9786139822515

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