Design of novel compounds with the potential of dual PPAR�/� modulation: For the management of metabolic syndrome - Couverture souple

Ellul, Claire ; Shoemake, Claire

9786139832439: Design of novel compounds with the potential of dual PPAR�/� modulation: For the management of metabolic syndrome

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ISBN 10 : 6139832438 ISBN 13 : 9786139832439

Editeur : LAP LAMBERT Academic Publishing, 2018

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2018
Langue: anglais
ISBN 10: 6139832438
ISBN 13: 9786139832439
Reliure: Broch�
Nombre de pages: 392
Coordonn�es du fabricant: non disponible
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Design of novel compounds with the potential of dual PPAR�/� modulation

Claire Ellul

Edit� par LAP LAMBERT Academic Publishing Jun 2018, 2018

ISBN 10 : 6139832438 ISBN 13 : 9786139832439

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This study sought to identify a single molecule capable of managing all three manifestations of metabolic syndrome-hyperglycaemia, dyslipidaemia and hypertension. Two Protein Data Bank (PDB) depositions; 3VN2 and 2P54, describing the bound co-ordinates of the Peroxisome Proliferator Activated Receptor (PPAR) partial agonist and Angiotensin II Receptor (Ang(II)R) blocker telmisartan and of the experimental PPAR fibrate agonist GW590735 - were selected and used to establish the baseline affinity that any designed molecule in this study should ideally exceed in order to be considered for further optimisation. The study consisted of two processes. The first was a fragment based de novo approach. The second approach was a Virtual Screening (VS) exercise. The molecular cohorts identified through both the de novo and VS approaches were filtered for Lipinski Rule compliance and processed further. Molecules exhibiting dual affinities exceeding baseline values were selected for further optimisation. The use of the 'tried and tested' Ang(II)R blocker and fibrate scaffolds as templates predisposes to the identification of novel structures devoid of unacceptable toxicity. 392 pp. Englisch. N� de r�f. du vendeur 9786139832439

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Design of novel compounds with the potential of dual PPAR�/a modulation

Claire Ellul|Claire Shoemake

Edit� par LAP LAMBERT Academic Publishing, 2018

ISBN 10 : 6139832438 ISBN 13 : 9786139832439

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Ellul ClaireClaire Ellul has been working as a shift pharmacist at Mater Dei Hospital and she obtained a Bachelor of Pharmacy degree at the University of Malta in 2009 - Claire Shoemake is a Pharmacist and a Medicinal and Computation. N� de r�f. du vendeur 385873313

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Design of novel compounds with the potential of dual PPARGamma/ modulation

Ellul, Claire

ISBN 10 : 6139832438 ISBN 13 : 9786139832439

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Design of novel compounds with the potential of dual PPAR�/� modulation | For the management of metabolic syndrome

Claire Ellul (u. a.)

Edit� par LAP LAMBERT Academic Publishing, 2018

ISBN 10 : 6139832438 ISBN 13 : 9786139832439

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Design of novel compounds with the potential of dual PPAR�/� modulation

Claire Ellul

Edit� par LAP LAMBERT Academic Publishing Jun 2018, 2018

ISBN 10 : 6139832438 ISBN 13 : 9786139832439

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -This study sought to identify a single molecule capable of managing all three manifestations of metabolic syndrome-hyperglycaemia, dyslipidaemia and hypertension. Two Protein Data Bank (PDB) depositions; 3VN2 and 2P54, describing the bound co-ordinates of the Peroxisome Proliferator Activated Receptor (PPAR) partial agonist and Angiotensin II Receptor (Ang(II)R) blocker telmisartan and of the experimental PPAR� fibrate agonist GW590735 - were selected and used to establish the baseline affinity that any designed molecule in this study should ideally exceed in order to be considered for further optimisation. The study consisted of two processes. The first was a fragment based de novo approach. The second approach was a Virtual Screening (VS) exercise. The molecular cohorts identified through both the de novo and VS approaches were filtered for Lipinski Rule compliance and processed further. Molecules exhibiting dual affinities exceeding baseline values were selected for further optimisation. The use of the 'tried and tested' Ang(II)R blocker and fibrate scaffolds as templates predisposes to the identification of novel structures devoid of unacceptable toxicity.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 392 pp. Englisch. N� de r�f. du vendeur 9786139832439

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Design of novel compounds with the potential of dual PPAR�/� modulation : For the management of metabolic syndrome

Claire Ellul

Edit� par LAP LAMBERT Academic Publishing

ISBN 10 : 6139832438 ISBN 13 : 9786139832439

Neuf Taschenbuch

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Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This study sought to identify a single molecule capable of managing all three manifestations of metabolic syndrome-hyperglycaemia, dyslipidaemia and hypertension. Two Protein Data Bank (PDB) depositions; 3VN2 and 2P54, describing the bound co-ordinates of the Peroxisome Proliferator Activated Receptor (PPAR) partial agonist and Angiotensin II Receptor (Ang(II)R) blocker telmisartan and of the experimental PPAR fibrate agonist GW590735 - were selected and used to establish the baseline affinity that any designed molecule in this study should ideally exceed in order to be considered for further optimisation. The study consisted of two processes. The first was a fragment based de novo approach. The second approach was a Virtual Screening (VS) exercise. The molecular cohorts identified through both the de novo and VS approaches were filtered for Lipinski Rule compliance and processed further. Molecules exhibiting dual affinities exceeding baseline values were selected for further optimisation. The use of the 'tried and tested' Ang(II)R blocker and fibrate scaffolds as templates predisposes to the identification of novel structures devoid of unacceptable toxicity. N� de r�f. du vendeur 9786139832439

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