Divalproex sodium floating microspheres - Design and Quantification - Couverture souple

Rajaram, Subashini; Thomas A, Arun Alphons; Murugan, Abirami

 
9786139893119: Divalproex sodium floating microspheres - Design and Quantification
Couverture souple
ISBN 10 : 6139893119 ISBN 13 : 9786139893119
Editeur : LAP LAMBERT Academic Publishing, 2018

Synopsis

Any drug delivery system that enhances the therapeutic effectiveness of incorporated drugs by providing sustained, controlled delivery and or targeting the drug to desired site is always invitable. Among various route of administration oral route is the most compact, painless, safest and least expensive, it is the most often used. The present study aimed to develop a floating microsphere of Divalproex sodium for Epilepsy. The microspheres were prepared by emulsification crosslinking method using gluteraldehyde as crosslinking agent and chitosan as polymer. The microspheres were characterized for pre and post compression evaluations. In- vitro percentage drug release results shown that there was markedly extended release when chitosan concentration and molecular weight was increased. This may due to crosslinking of aldehyde groups of the glutaraldehyde form covalent amine bonds with the amino groups of chitosan and also due to the resonance established with adjacent double ethylenic bonds via Schiff reaction.Thus, this approach could be beneficial for the treatment of epilepsy with improved dissolution and absorption.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2018
Langue
anglais
ISBN 10 
6139893119
ISBN 13 
9786139893119
Reliure
Broché
Nombre de pages
124
Coordonnées du fabricant
non disponible
Personne responsable
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