Solid Self Micron Emulsifying Drug Delivery System of Rosuvastatin: Noval Drug Delivery System (SSMEDDS) - Rosuvastatin Calcium - Couverture souple

Vishwakarma, Amit

Couverture souple

ISBN 10 : 6139912083 ISBN 13 : 9786139912087

Editeur : LAP LAMBERT Academic Publishing, 2020

Synopsis

The objective of present research work was to develop a self-emulsifying drug delivery system of Rosuvastatin Calcium (RC) for increasing its solubility, and oral bioavailability. Solubility of RC was determined in various vehicles. Oil, Surfactant and Cosurfactant were selected based on the solubility and HLB (Hydrophilic lipophilic balance) value. To identify the microemulsion existing zone Pseudo-ternary phase diagrams were constructed. Solubility analysis was also done for optimization of formulation. The optimised microemulsion formulation was evaluated for Powder X-Ray Diffraction (XRD), SEM (Scanning electron microscopy) analysis, globule size, zeta potential and phase separation study. Average globule size and zeta potential of the optimized microemulsion formulation were found to be 30 nm, and -11.5 mV, respectively. The viscosity and conductivity data indicated that the microemulsion was of the o/w type.The solubility of RC was successfully enhanced up to 82.32%. Percent drug release at the end of 60 min was found to be 76.74 %. The solubility of Rosuvastatin Calcium was significantly enhanced after formulating into self-emulsify microemulsion.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2020
• Langue: anglais
• ISBN 10: 6139912083
• ISBN 13: 9786139912087
• Reliure: Broché
• Nombre de pages: 92
• Coordonnées du fabricant: non disponible
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