Assessment of Euclea crispa leaf extracts against diarrhoea pathogens: In vitro assessment of E. crispa leaf extracts against Campylobacter spp. & Escherichia coli – common diarrhoeal agents - Couverture souple

Alayande, Kazeem Adekunle

Couverture souple

ISBN 10 : 6139915325 ISBN 13 : 9786139915323

Editeur : LAP LAMBERT Academic Publishing, 2018

Synopsis

Diarrhoea is a common childhood disease with high mortality rate. It is the second leading killer of children, nearly one fifth of the children under the age of 5 die due to dehydration or compromised immunity due to diarrhoeal infection. This study thus aimed at assessing effect of Euclea crispa leaf extract and its fractions against diarrhoea causing isolates and determining time-kill dynamics by the potent fractions. Susceptibility of isolates was determined via agar well diffusion while the minimum bacteriostatic and bactericidal concentrations were determined via agar dilution method. Time-Kill dynamics was evaluated over a period of 120 min against E. coli (1323) representing Gram-negative isolates. The lowest MIC (0.08 mg/ml) is exhibited by the fractions partitioned into ethyl acetate, n-butanol and water while that partitioned into n-hexane and chloroform is 0.16 mg/ml. Total mortality was achieved by the ethyl acetate fraction at a concentration of 2 × MIC after 120 min of contact time. This study showcase significant antidiarrhoeal potential of Euclea crispa leaf extracts and equally indicates a source of readily available therapeutic agent against diarrhoeal infection.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2018
• Langue: anglais
• ISBN 10: 6139915325
• ISBN 13: 9786139915323
• Reliure: Broché
• Nombre de pages: 52
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible