Dementia Confidential: Aiming for Normal Aging, versus Dementia - Couverture souple

D'Arrigo, Joseph

 
9786139936663: Dementia Confidential: Aiming for Normal Aging, versus Dementia
Couverture souple
ISBN 10 : 6139936667 ISBN 13 : 9786139936663
Editeur : LAP LAMBERT Academic Publishing, 2018

Synopsis

A frequent coexistence of cerebrovascular pathology and Alzheimer's disease pathology has been observed over past decades. Accordingly, there is much documentary evidence indicating that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, obesity, diabetes, smoking, hypertension, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. This book describes a multitasking combination therapeutic (i.e., biomimetic lipid nanocarrier for several drugs) which crosses the blood-brain barrier, and readily binds to populations of cell-surface scavenger receptors (mainly SR-BI) simultaneously in brain tissue. These same receptor classes have been extensively reported to occur prominently on various Alzheimer's-related cell types. Hence, this multitasking (targeted drug-delivery) therapeutic may also display greater effectiveness at different stages of Alzheimer’s disease. Such a multitasking therapeutic approach could be especially useful to pharmaceutical researchers, graduate students and medical professionals by representing a promising way to treat, delay, or even prevent the disease in the future.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2018
Langue
anglais
ISBN 10 
6139936667
ISBN 13 
9786139936663
Reliure
Broché
Nombre de pages
84
Coordonnées du fabricant
non disponible
Personne responsable
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