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Formulation Development and Evaluation of an Antiemetic Drug - Couverture souple

KUMAR, ABHISHEK; Kosey, Sourabh; Verma, Richa

 
9786139985852: Formulation Development and Evaluation of an Antiemetic Drug
Couverture souple
ISBN 10 : 6139985854 ISBN 13 : 9786139985852
Editeur : LAP LAMBERT Academic Publishing, 2019

Synopsis

Dolasetron Mesylate is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, dolasetron mesylate competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Oral film of dolasetron mesylate quickly disintegrates and dissolves, and can be administered without water, making them particularly suitable for geriatric patients and found faster action. Fast dissolving films (FDFs); have gained popularity not only in breath strips but also in personal care, food drug delivery markets. In this study, dolasetron mesylate fast dissolving films were prepared using polymer HPMC by solvent casting method. The six preliminary batches arranged/prepared to obtained final optimized batch. It was observed that concentration of polymer effects the formation of film and dissolution time of the formulations. F3 formulation is considered as the best according to the obtained results with disintegrating time of 47 sec and complete drug release in 47 min. Percent drug release and disintegration time was taken as responses for study which were found within the accepted ranges.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Dolasetron Mesylate is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, dolasetron mesylate competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Oral film of dolasetron mesylate quickly disintegrates and dissolves, and can be administered without water, making them particularly suitable for geriatric patients and found faster action. Fast dissolving films (FDFs); have gained popularity not only in breath strips but also in personal care, food drug delivery markets. In this study, dolasetron mesylate fast dissolving films were prepared using polymer HPMC by solvent casting method. The six preliminary batches arranged/prepared to obtained final optimized batch. It was observed that concentration of polymer effects the formation of film and dissolution time of the formulations. F3 formulation is considered as the best according to the obtained results with disintegrating time of 47 sec and complete drug release in 47 min. Percent drug release and disintegration time was taken as responses for study which were found within the accepted ranges.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2019
Langue
anglais
ISBN 10 
6139985854
ISBN 13 
9786139985852
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
Buchpark GmbH
https://www.buchpark.de

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Trebbin
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