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Pathogenesis of Balamuthia Amoebic Encephalitis: Amoebic transversal of central nervous system through blood-brain barrier to produce disease - Couverture souple
Synopsis
Balamuthia amoebic encephalitis (BAE) is a serious human brain disease (caused by Balamuthia mandrillaris) that almost always results in death. However, the pathogenesis and pathophysiology of BAE remains incompletely understood. An important step in BAE is amoebae invasion of the bloodstream followed by their haematogenous spread. Balamuthia entry into the central nervous system most likely occurs at the blood-brain barrier (BBB) sites. However, it is not clear how circulating amoebae inside blood cross BBB. This book therefore describes the Balamuthia interactions with human brain microvascular endothelial cells (HBMEC), which constitute the BBB. It is demonstrated that Balamuthia adopt both contact dependent (adhesion to and disruptions of HBMEC monolayer followed by cell cycle arrest) and contact independent mechanism (disruption of tight junctions proteins by metalloproteases and Ecto-ATPases and degradation of extracellular matrix, which provide structural and functional support to the brain tissue leading to BBB perturbations. Future work will continue to study Balamuthia encephalitis pathogenesis which should help identify potential targets for therapeutic interventions.
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Pathogenesis of Balamuthia Amoebic Encephalitis
Edité par
LAP LAMBERT Academic Publishing Jun 2020, 2020
ISBN 10 : 6200005605
ISBN 13 : 9786200005601
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Balamuthia amoebic encephalitis (BAE) is a serious human brain disease (caused by Balamuthia mandrillaris) that almost always results in death. However, the pathogenesis and pathophysiology of BAE remains incompletely understood. An important step in BAE is amoebae invasion of the bloodstream followed by their haematogenous spread. Balamuthia entry into the central nervous system most likely occurs at the blood-brain barrier (BBB) sites. However, it is not clear how circulating amoebae inside blood cross BBB. This book therefore describes the Balamuthia interactions with human brain microvascular endothelial cells (HBMEC), which constitute the BBB. It is demonstrated that Balamuthia adopt both contact dependent (adhesion to and disruptions of HBMEC monolayer followed by cell cycle arrest) and contact independent mechanism (disruption of tight junctions proteins by metalloproteases and Ecto-ATPases and degradation of extracellular matrix, which provide structural and functional support to the brain tissue leading to BBB perturbations. Future work will continue to study Balamuthia encephalitis pathogenesis which should help identify potential targets for therapeutic interventions. 208 pp. Englisch. N° de réf. du vendeur 9786200005601
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Pathogenesis of Balamuthia Amoebic Encephalitis
Edité par
LAP LAMBERT Academic Publishing, 2020
ISBN 10 : 6200005605
ISBN 13 : 9786200005601
Neuf
Couverture souple
Vendeur : moluna, Greven, Allemagne
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Matin AbdulAbdul Matin, PhD: studied Medical Microbiology (Parasitology) at Birkbeck, University of London, UK followed by Post Doc. with Immunopharmacology from School of Medicine, Southampton University Hospital, Southampton, UK. H. N° de réf. du vendeur 385881043
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Pathogenesis of Balamuthia Amoebic Encephalitis | Amoebic transversal of central nervous system through blood-brain barrier to produce disease
Edité par
LAP LAMBERT Academic Publishing, 2020
ISBN 10 : 6200005605
ISBN 13 : 9786200005601
Neuf
Taschenbuch
Vendeur : preigu, Osnabrück, Allemagne
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Taschenbuch. Etat : Neu. Pathogenesis of Balamuthia Amoebic Encephalitis | Amoebic transversal of central nervous system through blood-brain barrier to produce disease | Abdul Matin | Taschenbuch | 208 S. | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786200005601 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 118540722
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Pathogenesis of Balamuthia Amoebic Encephalitis
Edité par
LAP LAMBERT Academic Publishing Jun 2020, 2020
ISBN 10 : 6200005605
ISBN 13 : 9786200005601
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Balamuthia amoebic encephalitis (BAE) is a serious human brain disease (caused by Balamuthia mandrillaris) that almost always results in death. However, the pathogenesis and pathophysiology of BAE remains incompletely understood. An important step in BAE is amoebae invasion of the bloodstream followed by their haematogenous spread. Balamuthia entry into the central nervous system most likely occurs at the blood-brain barrier (BBB) sites. However, it is not clear how circulating amoebae inside blood cross BBB. This book therefore describes the Balamuthia interactions with human brain microvascular endothelial cells (HBMEC), which constitute the BBB. It is demonstrated that Balamuthia adopt both contact dependent (adhesion to and disruptions of HBMEC monolayer followed by cell cycle arrest) and contact independent mechanism (disruption of tight junctions proteins by metalloproteases and Ecto-ATPases and degradation of extracellular matrix, which provide structural and functional support to the brain tissue leading to BBB perturbations. Future work will continue to study Balamuthia encephalitis pathogenesis which should help identify potential targets for therapeutic interventions.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 208 pp. Englisch. N° de réf. du vendeur 9786200005601
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Pathogenesis of Balamuthia Amoebic Encephalitis : Amoebic transversal of central nervous system through blood-brain barrier to produce disease
Edité par
LAP LAMBERT Academic Publishing, 2020
ISBN 10 : 6200005605
ISBN 13 : 9786200005601
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Balamuthia amoebic encephalitis (BAE) is a serious human brain disease (caused by Balamuthia mandrillaris) that almost always results in death. However, the pathogenesis and pathophysiology of BAE remains incompletely understood. An important step in BAE is amoebae invasion of the bloodstream followed by their haematogenous spread. Balamuthia entry into the central nervous system most likely occurs at the blood-brain barrier (BBB) sites. However, it is not clear how circulating amoebae inside blood cross BBB. This book therefore describes the Balamuthia interactions with human brain microvascular endothelial cells (HBMEC), which constitute the BBB. It is demonstrated that Balamuthia adopt both contact dependent (adhesion to and disruptions of HBMEC monolayer followed by cell cycle arrest) and contact independent mechanism (disruption of tight junctions proteins by metalloproteases and Ecto-ATPases and degradation of extracellular matrix, which provide structural and functional support to the brain tissue leading to BBB perturbations. Future work will continue to study Balamuthia encephalitis pathogenesis which should help identify potential targets for therapeutic interventions. N° de réf. du vendeur 9786200005601
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