Les particules de poly (lactide-glycolide) ont été synthétisées par méthode d'évaporation de solvant avec deux méthodes pour obtenir des particules de taille différente. En changeant le pourcentage de polymère dans une solution de phase dispersée et le pourcentage de poly (alcool vinylique) en phase continue, des particules de morphologie et de dimensions différentes ont été préparées. Les particules avec un faible pourcentage de stabilisant avaient des surfaces rugueuses et des tailles plus grandes. En augmentant le pourcentage de polymère dans la phase dispersée de 1 à 2 %, la taille des particules a d'abord diminué, puis augmentée. Au fur et à mesure que les conditions du processus ont changé, des particules de taille submicronique ont été fabriquées à partir de solutions PLGA de différentes concentrations dans une solution de poly (alcool vinylique) à 1 %. Les résultats indiquent la haute sensibilité de la morphologie et des dimensions des particules de poly (lactide-glycolide) aux conditions du processus de fabrication. Les particules submicroniques ont été chargées avec le médicament anticancéreux Oxaliplatin. Le taux de charge du médicament était fonction de la viscosité de phase dispersée et des dimensions des gouttelettes. Le test de libération a montré la capacité des particules préparées à contrôler et retarder la libération d'oxaliplatine dans le milieu de libération pendant 96 heures.
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Poly (lactide-glycolide) particles were synthesized by solvent evaporation method with two methods to obtain particles of different size. By changing the percentage of polymer in dispersed phase solution and percentage of poly (vinyl alcohol) in continuous phase, particles with different morphology and dimensions were prepared. The particles with a low percentage of stabilizer had rough surfaces and larger sizes. By increasing the percentage of polymer in the dispersed phase from 1 to 2%, the particle size first decreased and then increased. As the process conditions changed, sub-micron-sized particles were made from PLGA solutions of varying concentrations in 1% poly (vinyl alcohol) solution. The results indicate the high sensitivity of the morphology and dimensions of poly (lactide-glycolide) particles to the manufacturing process conditions. The sub-micron particles were loaded with the anti-cancer drug Oxaliplatin. Drug loading rate was a function of dispersed phase viscosity and droplet dimensions. The release test showed the ability of the particles prepared to control and delay release of Oxaliplatin in the release medium for 96 hours. 116 pp. Englisch. N° de réf. du vendeur 9786200077127
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Poly (lactide-glycolide) particles were synthesized by solvent evaporation method with two methods to obtain particles of different size. By changing the percentage of polymer in dispersed phase solution and percentage of poly (vinyl alcohol) in continuous phase, particles with different morphology and dimensions were prepared. The particles with a low percentage of stabilizer had rough surfaces and larger sizes. By increasing the percentage of polymer in the dispersed phase from 1 to 2%, the particle size first decreased and then increased. As the process conditions changed, sub-micron-sized particles were made from PLGA solutions of varying concentrations in 1% poly (vinyl alcohol) solution. The results indicate the high sensitivity of the morphology and dimensions of poly (lactide-glycolide) particles to the manufacturing process conditions. The sub-micron particles were loaded with the anti-cancer drug Oxaliplatin. Drug loading rate was a function of dispersed phase viscosity and droplet dimensions. The release test showed the ability of the particles prepared to control and delay release of Oxaliplatin in the release medium for 96 hours. N° de réf. du vendeur 9786200077127
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Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Poly (lactide-glycolide) particles were synthesized by solvent evaporation method with two methods to obtain particles of different size. By changing the percentage of polymer in dispersed phase solution and percentage of poly (vinyl alcohol) in continuous phase, particles with different morphology and dimensions were prepared. The particles with a low percentage of stabilizer had rough surfaces and larger sizes. By increasing the percentage of polymer in the dispersed phase from 1 to 2%, the particle size first decreased and then increased. As the process conditions changed, sub-micron-sized particles were made from PLGA solutions of varying concentrations in 1% poly (vinyl alcohol) solution. The results indicate the high sensitivity of the morphology and dimensions of poly (lactide-glycolide) particles to the manufacturing process conditions. The sub-micron particles were loaded with the anti-cancer drug Oxaliplatin. Drug loading rate was a function of dispersed phase viscosity and droplet dimensions. The release test showed the ability of the particles prepared to control and delay release of Oxaliplatin in the release medium for 96 hours.Books on Demand GmbH, Überseering 33, 22297 Hamburg 116 pp. Englisch. N° de réf. du vendeur 9786200077127
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Vendeur : preigu, Osnabrück, Allemagne
Taschenbuch. Etat : Neu. PLGA Micro and nanoparticles for Cancer Treatment | Maryam Salmani Jajaei | Taschenbuch | 116 S. | Englisch | 2020 | Noor Publishing | EAN 9786200077127 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 118168547
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Vendeur : Mispah books, Redhill, SURRE, Royaume-Uni
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