Estimation of AntiParkinson's Drugs: Development of Validated Analytical Methods - Couverture souple

Chaudhari, Madhuri; Bedis, Smita; Garud, Aniket

Couverture souple

ISBN 10 : 6200093474 ISBN 13 : 9786200093479

Editeur : LAP LAMBERT Academic Publishing, 2019

Synopsis

Pramipexole hydrochloride (PPX) and ropinirole hydrochloride (RPN), are nonergot dopamine agonist, selective for dopamine D2 and D3 receptors, in contrast to ergot derivatives that also have activity at D1 type and other nondopaminergic neurotransmitter receptors, indicated for the treatment of the signs and symptoms of Parkinson's disease. The nigrostristrial neurodegeneration that proceeds over the cource of parkinson’s disease limits the no. of striatal nerve terminals that are available to decarboxylate levodopa to dopamine. Drugs (PPX and RPN) that act directly to stimulate dopamine receptors, however do not require functioning dopaminergic nerve terminals and can be useful in the management of last- stage disease problems during levodopa therapy. The present work deals with development of validated analytical methods for these antiparkinson’s agents in bulk and in their respective pharmaceutical dosage forms by RP-HPLC and HPTLC techniques and different UV spectrophotometric methods.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2019
• Langue: anglais
• ISBN 10: 6200093474
• ISBN 13: 9786200093479
• Reliure: Broché
• Nombre de pages: 180
• Coordonnées du fabricant: non disponible
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