Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors - Couverture souple

Muhanji, Clare

9786200458971: Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

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ISBN 10 : 6200458979 ISBN 13 : 9786200458971

Editeur : LAP LAMBERT Academic Publishing, 2019

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2019
Langue: anglais
ISBN 10: 6200458979
ISBN 13: 9786200458971
Reliure: Broch�
Nombre de pages: 256
Coordonn�es du fabricant: non disponible
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Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

Clare Muhanji

Edit� par LAP LAMBERT Academic Publishing Okt 2019, 2019

ISBN 10 : 6200458979 ISBN 13 : 9786200458971

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book describes the design and synthesis of bifunctional drugs combining a nucleoside (d4U) and non-nucleoside (HI-236) reverse transcriptase inhibitor linked via different spacers between C-5 of the NRTI and O-1 of the NNRTI. Three targets were successfully synthesized in a divergent manner from uridine in 13 steps for the butyne target and 19 steps for targets bearing PEG-propyne units using Sonogashira coupling as a key step. The most challenging step of the synthesis involved Boc deprotection and thiourea condensation in the final step, which suffered from anomeric cleavage with loss of the sugar moiety. As a result, the target with a three-carbon propynyl spacer could not be accessed. Progress towards the synthesis of a bifunctional system bearing a saturated and more flexible tether is highlighted in Chapter 4. The key reactions included Sonogashira coupling of iodo nucleosides, 2',3'-dideoxygenation of the vicinol diol, phenolic alkylation and condensation of amine with thiourea reagent. The synthesis surmounted several challenges, with chemoselective distinction of unsaturation via late introduction of the d4U double bond using Corey-Winter methodology. 256 pp. Englisch. N� de r�f. du vendeur 9786200458971

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Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

Clare Muhanji

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200458979 ISBN 13 : 9786200458971

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Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

Muhanji, Clare

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200458979 ISBN 13 : 9786200458971

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Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

Clare Muhanji

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200458979 ISBN 13 : 9786200458971

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Taschenbuch. Etat : Neu. Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors | Clare Muhanji | Taschenbuch | Englisch | 2019 | LAP LAMBERT Academic Publishing | EAN 9786200458971 | Verantwortliche Person f�r die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabr�ck, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand. N� de r�f. du vendeur 120472617

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Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

Clare Muhanji

Edit� par LAP LAMBERT Academic Publishing Okt 2019, 2019

ISBN 10 : 6200458979 ISBN 13 : 9786200458971

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book describes the design and synthesis of bifunctional drugs combining a nucleoside (d4U) and non-nucleoside (HI-236) reverse transcriptase inhibitor linked via different spacers between C-5 of the NRTI and O-1 of the NNRTI. Three targets were successfully synthesized in a divergent manner from uridine in 13 steps for the butyne target and 19 steps for targets bearing PEG-propyne units using Sonogashira coupling as a key step. The most challenging step of the synthesis involved Boc deprotection and thiourea condensation in the final step, which suffered from anomeric cleavage with loss of the sugar moiety. As a result, the target with a three-carbon propynyl spacer could not be accessed. Progress towards the synthesis of a bifunctional system bearing a saturated and more flexible tether is highlighted in Chapter 4. The key reactions included Sonogashira coupling of iodo nucleosides, 2',3'-dideoxygenation of the vicinol diol, phenolic alkylation and condensation of amine with thiourea reagent. The synthesis surmounted several challenges, with chemoselective distinction of unsaturation via late introduction of the d4U double bond using Corey-Winter methodology.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 256 pp. Englisch. N� de r�f. du vendeur 9786200458971

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Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

Muhanji, Clare

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200458979 ISBN 13 : 9786200458971

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Synthesis of [d4U]-Spacer-[HI-236] Bifunctional HIV-1 Reverse Transcriptase Inhibitors

Clare Muhanji

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200458979 ISBN 13 : 9786200458971

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This book describes the design and synthesis of bifunctional drugs combining a nucleoside (d4U) and non-nucleoside (HI-236) reverse transcriptase inhibitor linked via different spacers between C-5 of the NRTI and O-1 of the NNRTI. Three targets were successfully synthesized in a divergent manner from uridine in 13 steps for the butyne target and 19 steps for targets bearing PEG-propyne units using Sonogashira coupling as a key step. The most challenging step of the synthesis involved Boc deprotection and thiourea condensation in the final step, which suffered from anomeric cleavage with loss of the sugar moiety. As a result, the target with a three-carbon propynyl spacer could not be accessed. Progress towards the synthesis of a bifunctional system bearing a saturated and more flexible tether is highlighted in Chapter 4. The key reactions included Sonogashira coupling of iodo nucleosides, 2',3'-dideoxygenation of the vicinol diol, phenolic alkylation and condensation of amine with thiourea reagent. The synthesis surmounted several challenges, with chemoselective distinction of unsaturation via late introduction of the d4U double bond using Corey-Winter methodology. N� de r�f. du vendeur 9786200458971

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