Solubility Enhancement: Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion - Couverture souple

Sanklecha, Vishal ; Pande, Vishal

9786200471789: Solubility Enhancement: Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion

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ISBN 10 : 6200471789 ISBN 13 : 9786200471789

Editeur : LAP LAMBERT Academic Publishing, 2019

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�diteur: LAP LAMBERT Academic Publishing
Date d'�dition: 2019
Langue: anglais
ISBN 10: 6200471789
ISBN 13: 9786200471789
Reliure: Broch�
Nombre de pages: 56
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Solubility Enhancement

Vishal Sanklecha

Edit� par LAP LAMBERT Academic Publishing Nov 2019, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present study involved the design & development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD & the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology & swelling behaviour & analysis carried out using FTIR, DSC & powder XRD. The solubility & dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility & dissolution of azilsartain medoxomil by using polycarbophil & HPMC K4M, forming an effective carrierfor developing extended release matrix pellets. 56 pp. Englisch. N� de r�f. du vendeur 9786200471789

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Solubility Enhancement: Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion

Sanklecha, Vishal; Pande, Vishal

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Solubility Enhancement: Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion

Sanklecha, Vishal; Pande, Vishal

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Solubility Enhancement: Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion

Sanklecha, Vishal; Pande, Vishal

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Solubility Enhancement : Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion

Vishal Pande

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The present study involved the design & development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD & the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology & swelling behaviour & analysis carried out using FTIR, DSC & powder XRD. The solubility & dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility & dissolution of azilsartain medoxomil by using polycarbophil & HPMC K4M, forming an effective carrierfor developing extended release matrix pellets. N� de r�f. du vendeur 9786200471789

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Solubility Enhancement

Vishal Sanklecha|Vishal Pande

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sanklecha VishalVishal Sanklecha completed Post Graduation in Pharmaceutics from Sanjivani College of Pharmaceutical Education & Research, Koprgaon. He currently works at Wockhardt Research Centre in Biotech Formulation & Development. N� de r�f. du vendeur 497105556

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Solubility Enhancement

Vishal Sanklecha

Edit� par LAP LAMBERT Academic Publishing Nov 2019, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The present study involved the design & development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD & the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology & swelling behaviour & analysis carried out using FTIR, DSC & powder XRD. The solubility & dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility & dissolution of azilsartain medoxomil by using polycarbophil & HPMC K4M, forming an effective carrierfor developing extended release matrix pellets.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 56 pp. Englisch. N� de r�f. du vendeur 9786200471789

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Solubility Enhancement | Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion

Vishal Sanklecha (u. a.)

Edit� par LAP LAMBERT Academic Publishing, 2019

ISBN 10 : 6200471789 ISBN 13 : 9786200471789

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Taschenbuch. Etat : Neu. Solubility Enhancement | Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion | Vishal Sanklecha (u. a.) | Taschenbuch | Englisch | 2019 | LAP LAMBERT Academic Publishing | EAN 9786200471789 | Verantwortliche Person f�r die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabr�ck, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand. N� de r�f. du vendeur 120469452

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