FORMULATION AND EVALUATION OF SIMVASTATIN TABLET: FAST DISSOLVING TABLET - Couverture souple

PATEL, URVASHI; PATEL, HARSHIL

 
9786200539137: FORMULATION AND EVALUATION OF SIMVASTATIN TABLET: FAST DISSOLVING TABLET
Couverture souple
ISBN 10 : 6200539138 ISBN 13 : 9786200539137
Editeur : LAP LAMBERT Academic Publishing, 2020

Synopsis

To obtain an enhanced in-vitro dissolution rate of simvastatin by using Liquisolid technique and Liquisolid tablets were optimized by DoE approach 32 full factorial design using Design Expert Software.The liquisolid tablets were formulated by using propylene glycol (PG), as liquid vehicle, Avicel PH-102 as a carrier material, Aerosil as a coating material, and aspartame as sweetener and Kyron 314 as a superdisintegrant. The new mathematical model 32 full factorial design was utilized to formulate various liquisolid powder systems and to calculate amount of carrier material and coating material.Simvasatin Liquisolid compacts enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique. Hence, this research work may be useful to formulate fast disintegrating Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2020
Langue
anglais
ISBN 10 
6200539138
ISBN 13 
9786200539137
Reliure
Broché
Nombre de pages
124
Coordonnées du fabricant
non disponible
Personne responsable
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