Drug-excipient-shell interactions using thermoplastic capsules - Couverture souple

Misic, Zdravka; Kuentz, Martin; Imanidis, Georgios

 
9786202007146: Drug-excipient-shell interactions using thermoplastic capsules

Synopsis

This book introduced novel starch-based thermoplastic capsules (S-PVA-Cs) and demonstrated their advantage over SGCs with respect to hydrophilic lipid-based formulations. Release studies in biorelevant media revealed differences in how formulations hydrated and interacted with the shell material. Drug-excipient-shell interactions were observed in various capsule types (SGCs, S-PVA-Cs, and VegaGels®) at different levels of biopharmaceutical in vitro testing. A better mechanistic understanding was attained that may guide future development of soft capsule products.

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