Fatty acids and experimental hepatitis - Couverture souple

Hussein, Jihan; Medhat, Dalia; Fahmy, Hebatalla

Couverture souple

ISBN 10 : 6202011963 ISBN 13 : 9786202011969

Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

Hepatitis caused by virus infection, alcohol, bacteria and many hepatotoxic agents is known to be a serious clinical syndrome that could result in hepatocytes necrosis.Various models of experimental hepatitis are used; one of which is that induced by D-Galactosamine (D-GalN) .This model is identical to human viral hepatitis in both morphological and functional characters.Lipopolysaccharide (LPS) together with D-galactosamine (D-Ga1N) induce pronounced secretion of pro-inflammatory mediators by Kupffer cells which have been proved to be early hepatic injury stimulators . Omega-3 (n-3) represents a big family of fatty acids (essential fatty acids) that consists of eicosapentaenoic acid (EPA), α-linolenic acid (ALA) and docosahexaenoic acid (DHA) .Omega-3 and omega-6 have the ability to modulate immune system components (production, releasing and activity), therefore omega -3 was found to have anti-inflammatory role while omega -6 is characterized by a pro-inflammatory effect. Different mechanisms were suggested in this point including prostaglandin production, cell membrane fluidity and regulation of gene expression .

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2017
• Langue: anglais
• ISBN 10: 6202011963
• ISBN 13: 9786202011969
• Reliure: Broché
• Nombre de pages: 64
• Coordonnées du fabricant: non disponible
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