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Oral Gastroretentive Floating In-Situ Gelling System of Furosemide: Controlled Release Dosage Form - Couverture souple

Alhamdany, Anas T.; Maraie, Nidhal K.

 
9786202066792: Oral Gastroretentive Floating In-Situ Gelling System of Furosemide: Controlled Release Dosage Form
Couverture souple
ISBN 10 : 6202066792 ISBN 13 : 9786202066792
Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

Floating in-situ gel is one of the gastroretentive drug delivery systems represents a revolution in the oral controlled release dosage forms in comparative with conventional oral liquids. They prolong the residence time of the drug that has a narrow absorption window in the absorptive sites like stomach or upper gastrointestinal (GI) tract; since they have a bulk density lower than gastric fluids. Thus they remain buoyant in the stomach without affecting the gastric emptying rate until all the drug release continuously at a slow rate. Furosemide is a high ceiling loop diuretic widely used for patients with congestive heart failure (CHF) to get rid of excess body water, reducing blood pressure, and mobilizing edemas. This study involved formulation of furosemide oral solution which undergoes gelation upon direct contact with gastric fluid and floated using either primary polymers as sodium alginate and gellan gum or in combination with secondary polymers as iota carrageenan and HPMC. Different evaluations were performed on all 35 in-situ gel formulas to measure the gel strength, gelation time, swelling index, content uniformity, floating lag time, floating duration, pH and density.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Floating in-situ gel is one of the gastroretentive drug delivery systems represents a revolution in the oral controlled release dosage forms in comparative with conventional oral liquids. They prolong the residence time of the drug that has a narrow absorption window in the absorptive sites like stomach or upper gastrointestinal (GI) tract; since they have a bulk density lower than gastric fluids. Thus they remain buoyant in the stomach without affecting the gastric emptying rate until all the drug release continuously at a slow rate. Furosemide is a high ceiling loop diuretic widely used for patients with congestive heart failure (CHF) to get rid of excess body water, reducing blood pressure, and mobilizing edemas. This study involved formulation of furosemide oral solution which undergoes gelation upon direct contact with gastric fluid and floated using either primary polymers as sodium alginate and gellan gum or in combination with secondary polymers as iota carrageenan and HPMC. Different evaluations were performed on all 35 in-situ gel formulas to measure the gel strength, gelation time, swelling index, content uniformity, floating lag time, floating duration, pH and density.

Biographie de l'auteur

Anas Alhamdany has completed MSC from College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq. Now he is working as academian and researcher in the same college. Co-author - Prof. Dr. Nidhal K. Maraie who has a number of publications in various national and international journals also has a wide experience in the nano pharmaceutical field.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2017
Langue
anglais
ISBN 10 
6202066792
ISBN 13 
9786202066792
Reliure
Broché
Nombre de pages
148
Coordonnées du fabricant
non disponible
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